Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

Volume: 24, Issue: 1, Pages: 132 - 141
Published: Jan 1, 2014
Abstract
RNA-guided endonucleases (RGENs), derived from the prokaryotic adaptive immune system known as CRISPR/Cas, enable targeted genome engineering in cells and organisms. RGENs are ribonucleoproteins that consist of guide RNA and Cas9, a protein component originated from Streptococcus pyogenes. These enzymes cleave chromosomal DNA, whose sequence is complementary, to guide RNA in a targeted manner, producing site-specific DNA double-strand breaks...
Paper Details
Title
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Published Date
Jan 1, 2014
Volume
24
Issue
1
Pages
132 - 141
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