Regulation of activation and recombination of the murine Igκ locus

Summary: The murine immunoglobulin (Ig) κ locus has been intensively studied in an attempt to understand its developmentally regulated activation for both transcription and V(D)J recombination. A variety of signaling proteins, cis ‐acting DNA elements, and trans ‐acting DNA‐binding proteins have been discovered and shown to be involved in the regulated changes in chromatin structure, which are associated with recombinase accessibility. In...