Evolution of histone 2A for chromatin compaction in eukaryotes
Abstract
During eukaryotic evolution, genome size has increased disproportionately to nuclear volume, necessitating greater degrees of chromatin compaction in higher eukaryotes, which have evolved several mechanisms for genome compaction. However, it is unknown whether histones themselves have evolved to regulate chromatin compaction. Analysis of histone sequences from 160 eukaryotes revealed that the H2A N-terminus has systematically acquired arginines...
Paper Details
Title
Evolution of histone 2A for chromatin compaction in eukaryotes
Published Date
Jun 17, 2014
Journal
Volume
3
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