Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
Abstract
Immune checkpoint inhibitors are effective cancer treatments, but molecular determinants of clinical benefit are unknown. Ipilimumab and tremelimumab are antibodies against cytotoxic T-lymphocyte antigen 4 (CTLA-4). Anti-CTLA-4 treatment prolongs overall survival in patients with melanoma. CTLA-4 blockade activates T cells and enables them to destroy tumor cells.We obtained tumor tissue from patients with melanoma who were treated with...
Paper Details
Title
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
Published Date
Dec 4, 2014
Volume
371
Issue
23
Pages
2189 - 2199
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