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A 12-Week Aerobic Exercise Program Reduces Hepatic Fat Accumulation and Insulin Resistance in Obese, Hispanic Adolescents

Published on Feb 1, 2010in Obesity3.97
· DOI :10.1038/oby.2009.274
Gert Jan Van Der Heijden2
Estimated H-index: 2
(BCM: Baylor College of Medicine),
Zhiyue J. Wang32
Estimated H-index: 32
+ 4 AuthorsAgneta L. Sunehag24
Estimated H-index: 24
(BCM: Baylor College of Medicine)
Cite
Abstract
The rise in obesity-related morbidity in children and adolescents requires urgent prevention and treatment strategies. Currently, only limited data are available on the effects of exercise programs on insulin resistance, and visceral, hepatic, and intramyocellular fat accumulation. We hypothesized that a 12-week controlled aerobic exercise program without weight loss reduces visceral, hepatic, and intramyocellular fat content and decreases insulin resistance in sedentary Hispanic adolescents. Twenty-nine postpubertal (Tanner stage IV and V), Hispanic adolescents, 15 obese (7 boys, 8 girls; 15.6 +/- 0.4 years; 33.7 +/- 1.1 kg/m(2); 38.3 +/- 1.5% body fat) and 14 lean (10 boys, 4 girls; 15.1 +/- 0.3 years; 20.6 +/- 0.8 kg/m(2); 18.9 +/- 1.5% body fat), completed a 12-week aerobic exercise program (4 x 30 min/week at >= 70% of peak oxygen consumption (VO(2) peak)). Measurements of cardiovascular fitness, visceral, hepatic, and intramyocellular fat content (magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS)), and insulin resistance were obtained at baseline and postexercise. In both groups, fitness increased (obese: 13 +/- 2%, lean: 16 +/- 4%; both P <0.01). In obese participants, intramyocellular fat remained unchanged, whereas hepatic fat content decreased from 8.9 +/- 3.2 to 5.6 +/- 1.8%; P <0.05 and visceral fat content from 54.7 +/- 6.0 to 49.6 +/- 5.5 cm(2); P <0.05. Insulin resistance decreased indicated by decreased fasting insulin (21.8 +/- 2.7 to 18.2 +/- 2.4 mu U/ml; P <0.01) and homeostasis model assessment of insulin resistance (HOMA(IR)) (4.9 +/- 0.7 to 4.1 +/- 0.6; P <0.01). The decrease in visceral fat correlated with the decrease in fasting insulin (R(2) = 0.40; P <0.05). No significant changes were observed in any parameter in lean participants except a small increase in lean body mass (LBM). Thus, a controlled aerobic exercise program, without weight loss, reduced hepatic and visceral fat accumulation, and decreased insulin resistance in obese adolescents.
  • References (48)
  • Citations (145)
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References48
Newest
Published on Apr 1, 2009in Hypertension7.02
Patrick Mathieu46
Estimated H-index: 46
(Laval University),
Paul Poirier53
Estimated H-index: 53
(Laval University)
+ 2 AuthorsJean-Pierre Després110
Estimated H-index: 110
(Laval University)
The worldwide epidemic of obesity, fostered by the modern lifestyle characterized by the lack of physical activity and an energy-dense diet, has contributed to create an unprecedented condition in human history where a majority of overfed individuals will soon surpass the number of malnourished.1 Obesity-associated disorders, such as diabetes mellitus, an atherogenic dyslipidemia, and hypertension, have undoubtedly contributed to create an atherosclerosis-prone environment and thereby the develo...
Published on Oct 1, 2008in Obesity3.97
Michaela C. Devries21
Estimated H-index: 21
(McMaster University),
Imtiaz A. Samjoo10
Estimated H-index: 10
(McMaster University)
+ 1 AuthorsMark A. Tarnopolsky93
Estimated H-index: 93
(McMaster University)
Obesity and physical inactivity are independent risk factors for the development of nonalcoholic fatty liver disease (NAFLD). We determined the effect of endurance exercise training on hepatic lipid content and hepatic enzyme concentration in men and women. Waist circumference (WC), percent body fat (BF), computed tomography (CT) scans for liver attenuation (inverse relationship with hepatic lipid), bilirubin, alanine aminotransferase (ALT), and γ-glutamyltransferase (GGT) plasma concentrations ...
Published on Jun 1, 2008in Obesity3.97
D. Enette Larson-Meyer21
Estimated H-index: 21
(UW: University of Wyoming),
Bradley R. Newcomer24
Estimated H-index: 24
(UAB: University of Alabama at Birmingham)
+ 7 AuthorsEric Ravussin99
Estimated H-index: 99
(LSU: Louisiana State University)
D. Enette Larson-Meyer, Bradley R. Newcomer, Leonie K. Heilbronn, Julia Volaufova, Steven R. Smith, Anthony J. Alfonso, Michael Lefevre, Jennifer C. Rood, Donald A. Williamson, Eric Ravussin and The Pennington CALERIE Team
Published on Jun 1, 2008in The Journal of Clinical Endocrinology and Metabolism5.61
Claudio Maffeis36
Estimated H-index: 36
,
Riccardo Manfredi39
Estimated H-index: 39
+ 4 AuthorsRiccardo C. Bonadonna53
Estimated H-index: 53
(University of Verona)
Aim: Our aim was to explore the relationship between insulin sensitivity, body fat distribution, ectopic (liver and skeletal muscle) fat deposition, adipokines (leptin and adiponectin), and inflammation markers (highly sensitive C-reactive protein, IL-6, IL-10, and TNF-α) in prepubertal children. Subjects and Methods: Thirty overweight and obese children (16 males and 14 females with body mass index z-score range of 1.1–3.2) were recruited. Body fat distribution and fat accumulation in liver and...
Published on Feb 1, 2008in Diabetes7.20
Sara E. Taksali19
Estimated H-index: 19
,
Sonia Caprio65
Estimated H-index: 65
+ 10 AuthorsMary Savoye24
Estimated H-index: 24
OBJECTIVE— To explore whether an imbalance between the visceral and subcutaneous fat depots and a corresponding dysregulation of the adipokine milieu is associated with excessive accumulation of fat in the liver and muscle and ultimately with insulin resistance and the metabolic syndrome. RESEARCH DESIGN AND METHODS— We stratified our multi-ethnic cohort of 118 obese adolescents into tertiles based on the proportion of abdominal fat in the visceral depot. Abdominal and liver fat were measured by...
Published on Jan 1, 2008in Exercise and Sport Sciences Reviews4.74
Gabriel Q. Shaibi23
Estimated H-index: 23
,
Christian K. Roberts36
Estimated H-index: 36
(SC: University of Southern California),
Michael I. Goran85
Estimated H-index: 85
(SC: University of Southern California)
In parallel with the pediatric obesity epidemic, the incidence of impaired glucose tolerance and type 2 diabetes has increased among youth. Insulin resistance is thought to be central to the pathophysiology of these obesity-related disorders. A growing body of literature suggests that exercise may ameliorate insulin resistance and thus potentially reduce the long-term diabetes risk in overweight youth
Published on Nov 1, 2007in The Journal of Clinical Endocrinology and Metabolism5.61
L. Bell6
Estimated H-index: 6
,
Katie Watts11
Estimated H-index: 11
(Telethon Institute for Child Health Research)
+ 8 AuthorsTimothy W. Jones48
Estimated H-index: 48
(Telethon Institute for Child Health Research)
Context: The number of obese children with insulin resistance and type 2 diabetes is increasing, but the best management strategy is not clear. Objective: The objective of this study was to assess the effect of a structured 8-wk exercise training program on insulin resistance and changes in body composition in obese children. Design: The study was 8 wk of structured supervised exercise intervention with outcome measures before and after the exercise period. Subjects: Fourteen obese children (12....
Published on Sep 1, 2007in Metabolism-clinical and Experimental6.51
Danielle Arisa Caranti14
Estimated H-index: 14
(UNIFESP: Federal University of São Paulo),
Marco Túlio de Mello40
Estimated H-index: 40
(UNIFESP: Federal University of São Paulo)
+ 8 AuthorsSergio Tufik56
Estimated H-index: 56
(UNIFESP: Federal University of São Paulo)
Visceral fat is highly correlated with metabolic syndrome in obese adolescents. The aims of this study were to determine the prevalence of metabolic syndrome and to assess the effect of a long-term (1 year) intervention with multidisciplinary therapy in predicting metabolic syndrome among obese adolescents, as well as to compare short- with long-term therapy. Eighty-three postpuberty obese adolescents were recruited, including 37 boys (body mass index [BMI], 36.19 ± 3.85 kg/m 2 ) and 46 girls (B...
Published on Jul 3, 2007in Diabetologia7.11
Tracey McLaughlin40
Estimated H-index: 40
(Stanford University),
Arthur Sherman45
Estimated H-index: 45
(NIH: National Institutes of Health)
+ 5 AuthorsSamuel W. Cushman55
Estimated H-index: 55
(NIH: National Institutes of Health)
Aims/hypothesis The biological mechanism by which obesity predisposes to insulin resistance is unclear. One hypothesis is that larger adipose cells disturb metabolism via increased lipolysis. While studies have demonstrated that cell size increases in proportion to BMI, it has not been clearly shown that adipose cell size, independent of BMI, is associated with insulin resistance. The aim of this study was to test this widely held assumption by comparing adipose cell size distribution in 28 equa...
Published on Jul 1, 2007in Medicine and Science in Sports and Exercise4.48
Mariam Ischander1
Estimated H-index: 1
,
Frank Zaldivar29
Estimated H-index: 29
+ 5 AuthorsMargaret Schneider22
Estimated H-index: 22
Purpose: Physical inactivity is deleterious to health, but it has been difficult to determine the extent to which these effects are attributable to abnormal body composition or to factors related to physical activity alone. To begin to gauge independent effects of physical activity on health risk, we matched by BMI two groups of normal-weight adolescent females, one physically active (all participants in high school sports), and one sedentary. Methods: Thirty-seven sedentary and 37 physically ac...
Cited By145
Newest
Published on 2019in Molecular therapy. Nucleic acids5.92
Suixin Liu3
Estimated H-index: 3
(CSU: Central South University),
Fan Zheng3
Estimated H-index: 3
(CSU: Central South University)
+ 3 AuthorsYing Cai3
Estimated H-index: 3
(CSU: Central South University)
Abstract Insulin resistance (IR) is the primary pathological mechanism underlying type 2 diabetes mellitus (T2DM). Here, the study aimed to ascertain whether and how exercise mediates IR in T2DM. An in vivo mouse model of high-fat diet-induced IR and an in vitro high glucose-induced IR model were constructed. High lncRNA MALAT1 expression was detected in T2MD, and was positively correlated with HOMA-IR and resistin levels. Then, sh-MALAT1 or pcDNA-MALAT1 was delivered into human umbilical vein e...
Colin S. McCoin8
Estimated H-index: 8
(KU: University of Kansas),
Alex Von Schulze2
Estimated H-index: 2
(KU: University of Kansas)
+ 9 AuthorsKartik Shankar36
Estimated H-index: 36
(University of Arkansas for Medical Sciences)
The impact of sexual dimorphism and mitophagy on hepatic mitochondrial adaptations during the treatment of steatosis with physical activity are largely unknown. Here, we tested if deficiencies in l...
Published on May 1, 2019in Physiological Reports
Sechang Oh8
Estimated H-index: 8
(University of Tsukuba),
Natsumi Oshida (University of Tsukuba)+ 6 AuthorsJunichi Shoda34
Estimated H-index: 34
(University of Tsukuba)
Published on Mar 1, 2019in The Journal of Pediatrics3.74
SoJung Lee34
Estimated H-index: 34
(Kyung Hee University),
Ingrid Libman26
Estimated H-index: 26
(University of Pittsburgh)
+ 4 AuthorsSilva Arslanian62
Estimated H-index: 62
(University of Pittsburgh)
Objective To examine whether a combined aerobic exercise and resistance exercise is more effective than either aerobic exercise or resistance exercise alone in improving insulin sensitivity and reducing total adiposity and ectopic fat in adolescents. Study design A total of 118 sedentary adolescents with overweight/obesity (body mass index >85th percentile, 12-17 years) were recruited from October 2013 through April 2017 at Children's Hospital of Pittsburgh. Participants were randomized to 1 of ...
Published on Jan 1, 2019in Sports Medicine7.58
Takashi Abe21
Estimated H-index: 21
(University of Mississippi),
Jeremy P. Loenneke33
Estimated H-index: 33
(University of Mississippi),
Robert S. Thiebaud23
Estimated H-index: 23
(Texas Wesleyan University)
Fat-free body mass (FFM) is a surrogate for skeletal muscle mass and is often used for the normalization of several physiological variables (e.g., oxygen uptake). However, FFM includes non-skeletal muscle components such as the fat-free component of adipose tissue fat cells. As the amount of adipose tissue mass increases, the FFM will also increase and be included in the measurement of FFM. Therefore, FFM may not be an appropriate indicator of muscle mass when targeting individuals with a large ...
Paulina Cruz1
Estimated H-index: 1
(WashU: Washington University in St. Louis),
Andrea Granados2
Estimated H-index: 2
(WashU: Washington University in St. Louis)
Latino youth have the highest prevalence of overweight and obesity among all ethnic groups and are disproportionally affected by pre diabetes and type 2 diabetes (T2DM). Interventions that effectively reduce the risk of pre diabetes and T2DM in this population are urgently needed. Studies have shown that without any change, 50% of Latino children and adolescents will develop T2DM. This has important public health implications. Few pharmacologic options are approved for use in the pediatric popul...
Published on Dec 1, 2018in Trials1.98
Katherine González-Ruíz9
Estimated H-index: 9
(Del Rosario University),
Jorge Enrique Correa Bautista11
Estimated H-index: 11
(Del Rosario University)
+ 12 AuthorsEmilio González Jiménez12
Estimated H-index: 12
(UGR: University of Granada)
Background A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month ex...
Published on Oct 23, 2018in Frontiers in Physiology3.20
Cristian Álvarez13
Estimated H-index: 13
,
Rodrigo Ramírez-Campillo15
Estimated H-index: 15
+ 2 AuthorsMikel Izquierdo51
Estimated H-index: 51
(ISCIII: Instituto de Salud Carlos III)
Background:Exercise is known to improve cardiometabolic outcomes; however, results are typically reported as mean values, and there is wide interindividual variability in terms of response that has not been explored in populations at risk for hypertension.Our aim was to investigate both the effects on and the prevalence of nonresponders (NRs) for decreasing blood pressure (BP) and other risk factors among prehypertensive women after long-term high-intensity interval training(HIIT).A secondary ai...
Published on Oct 1, 2018in Obesity Reviews8.19
Jack A. Sargeant2
Estimated H-index: 2
(NIHR: National Institute for Health Research),
Laura J. Gray60
Estimated H-index: 60
(University of Leicester)
+ 5 AuthorsJames A. King15
Estimated H-index: 15
(NIHR: National Institute for Health Research)
This systematic review and meta-analysis determined the impact of structured exercise training, and the influence of associated weight loss, on intrahepatic triglyceride (IHTG) in individuals with non-alcoholic fatty liver disease (NAFLD). It also examined its effect on hepatic insulin sensitivity in individuals with or at increased risk of NAFLD. Analyses were restricted to studies using magnetic resonance spectroscopy or liver biopsy for the measurement of IHTG and isotope-labelled glucose tra...