Effect of dopamine D1 receptor antagonist SCH23390 and D1 agonist A77636 on active allothetic place avoidance, a spatial cognition task

Central dopamine neurotransmission is implicated in several physiological and pathophysiological neural processes. In the past years, attention was paid to the role of dopaminergic signaling in the cognitive processes. In the present study, we investigate role of dopamine D1 receptors in spatial cognition using systemic administration of D1-specific agonist A77636 and D1 antagonist SCH23390. Subsequently, animals were tested in a spatial...