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TRANSFER OF DELAYED HYPERSENSITIVITY TO SKIN HOMOGRAFTS WITH LEUKOCYTE EXTRACTS IN MAN

Published on Jan 1, 1960in Journal of Clinical Investigation12.282
· DOI :10.1172/JCI104018
H S Lawerence26
Estimated H-index: 26
,
F T Rapaport18
Estimated H-index: 18
+ 1 AuthorsWilliam S. Tillett24
Estimated H-index: 24
Abstract
  • References (34)
  • Citations (94)
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Summary and Conclusions 1.Generalized delayed sensitivity to coccidioidin can be transferred in human subjects with DNase-treated leukocyte extracts obtained from sensitive donors. This has been accomplished in 23 out of 27 consecutive attempts with leukocyte extracts obtained from moderately to markedly sensitive donors, and in 5 out of 8 consecutive attempts with leukocytes obtained from minimally to moderately sensitive donors. 2.Attempts to transfer coccidioidin sensitivity with leukocyte ex...
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In guinea pigs it has been possible to transfer allergic contact sensitivity regularly, using peritoneal exudates (1), minced spleen (2), lymph nodes (2) and other leukocyte sources (3, 4). Mononuclear cells, most likely lymphocytes, are thought to be the cells containing the transfer factor (5). In man, on the other hand, instances of successful transfer have been so few that most workers are not persuaded that this phenomenon has been conclusively demonstrated (6, 7, 8, 9, 10). The explanation...
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