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The effect of dietary resistant starch type 2 on the microbiota and markers of gut inflammation in rural Malawi children

Published on Dec 1, 2015in Mbio 6.75
· DOI :10.1186/s40168-015-0102-9
M. Isabel Ordiz8
Estimated H-index: 8
(UW: University of Washington),
Thaddaeus May3
Estimated H-index: 3
(BCM: Baylor College of Medicine)
+ 10 AuthorsMark J. Manary44
Estimated H-index: 44
Cite
Abstract
Background Resistant starch (RS) decreases intestinal inflammation in some settings. We tested the hypothesis that gut inflammation will be reduced with dietary supplementation with RS in rural Malawian children. Eighteen stunted 3–5-year-old children were supplemented with 8.5 g/day of RS type 2 for 4 weeks. The fecal samples were analyzed for the microbiota, the microbiome, short chain fatty acids, metabolome, and proteins indicative of inflammation before and after the intervention. Subjects served as their own controls.
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  • References (45)
  • Citations (23)
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References45
Newest
Walter Alexander6
Estimated H-index: 6
“Repeat treatment with rifaximin led to significantly greater likelihood of improvement in IBS-related symptoms than placebo for abdominal pain and stool consistency, bloating, and urgency,” Dr. Chey concluded in his oral presentation of TARGET 3 results. This randomized, double-blind trial tested rifaximin in 636 irritable bowel syndrome (IBS) patients who had responded to an initial course of rifaximin but had a recurrence within 18 weeks. Repeat treatment consisted of two courses of rifaximin...
Published on Jul 1, 2015in Scientific Reports 4.01
Jiro Nakayama36
Estimated H-index: 36
,
Koichi Watanabe2
Estimated H-index: 2
+ 26 AuthorsLiang Zhao1
Estimated H-index: 1
(CAU: China Agricultural University)
Asia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures and dietary habits. To address the diversity in their gut microbiota, we characterized the bacterial community in fecal samples obtained from 303 school-age children living in urban or rural regions in five countries spanning temperate and tropical areas of Asia. The microbiota profiled for the 303 subjects were classified into two enterotype-like clusters, eac...
Published on Apr 1, 2015in Journal of Trace Elements in Medicine and Biology 2.90
Thaddaeus May3
Estimated H-index: 3
(BCM: Baylor College of Medicine),
Claire Westcott3
Estimated H-index: 3
(University of Colorado Denver)
+ 10 AuthorsGraeme P. Young46
Estimated H-index: 46
(Flinders University)
Abstract Objective This study tested the hypothesis that Malawian children at risk for zinc deficiency will have reduced endogenous fecal zinc (EFZ) and increased net absorbed zinc (NAZ) following the addition of high amylose maize resistant starch (RS) to their diet. Methods This was a small controlled clinical trial to determine the effects of added dietary RS on zinc homeostasis among 17 stunted children, aged 3–5 years consuming a plant-based diet and at risk for perturbed zinc homeostasis. ...
Published on Nov 1, 2014in Clinical Infectious Diseases 9.05
Gerald T. Keusch16
Estimated H-index: 16
(BU: Boston University),
Donna M. Denno18
Estimated H-index: 18
(UW: University of Washington)
+ 15 AuthorsPhillip I. Tarr63
Estimated H-index: 63
(WashU: Washington University in St. Louis)
Stunting is common in young children in developing countries, and is associated with increased morbidity, developmental delays, and mortality. Its complex pathogenesis likely involves poor intrauterine and postnatal nutrition, exposure to microbes, and the metabolic consequences of repeated infections. Acquired enteropathy affecting both gut structure and function likely plays a significant role in this outcome, especially in the first few months of life, and serve as a precursor to later intera...
Published on Nov 1, 2014in Clinical Infectious Diseases 9.05
Gerald T. Keusch16
Estimated H-index: 16
(Boston University Medical Campus),
Donna M. Denno18
Estimated H-index: 18
(UW: University of Washington)
+ 15 AuthorsPhillip I. Tarr63
Estimated H-index: 63
(WashU: Washington University in St. Louis)
Published on Nov 1, 2014in Paediatrics and International Child Health 1.36
Andrew J. Prendergast33
Estimated H-index: 33
(Johns Hopkins University),
Jean H Humphrey ScD37
Estimated H-index: 37
(Johns Hopkins University)
AbstractLinear growth failure is the most common form of undernutrition globally. With an estimated 165 million children below 5 years of age affected, stunting has been identified as a major public health priority, and there are ambitious targets to reduce the prevalence of stunting by 40% between 2010 and 2025. We view this condition as a ‘stunting syndrome’ in which multiple pathological changes marked by linear growth retardation in early life are associated with increased morbidity and mort...
Published on Sep 9, 2014in Mbio 6.75
Elizabeth A. Cameron7
Estimated H-index: 7
(UM: University of Michigan),
Kurt J. Kwiatkowski5
Estimated H-index: 5
(UM: University of Michigan)
+ 3 AuthorsEric C. Martens32
Estimated H-index: 32
(UM: University of Michigan)
ABSTRACT To compete for the dynamic stream of nutrients flowing into their ecosystem, colonic bacteria must respond rapidly to new resources and then catabolize them efficiently once they are detected. The Bacteroides thetaiotaomicron starch utilization system (Sus) is a model for nutrient acquisition by symbiotic gut bacteria, which harbor thousands of related Sus-like systems. Structural investigation of the four Sus outer membrane proteins (SusD, -E, -F, and -G) revealed that they contain a t...
Published on May 1, 2014in British Journal of Nutrition 3.32
Anne Krog Ingerslev4
Estimated H-index: 4
(AU: Aarhus University),
Peter Kappel Theil4
Estimated H-index: 4
(AU: Aarhus University)
+ 2 AuthorsKnud Erik Bach Knudsen33
Estimated H-index: 33
(AU: Aarhus University)
The effects of increased colonic fermentation of dietary fibres (DF) on the net portal flux (NPF) of carbohydrate-derived metabolites (glucose, SCFA and, especially, butyrate), hormones (insulin, C-peptide, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide) and NEFA were studied in a healthy catheterised pig model. A total of six pigs weighing 59 (SEM 1·6) kg were fitted with catheters in the mesenteric artery and in the portal and hepatic veins, and a flow probe around the po...
Published on Apr 1, 2014in Scandinavian Journal of Gastroenterology 2.15
Klaus Theede6
Estimated H-index: 6
(Copenhagen University Hospital),
Marianne Kiszka-Kanowitz3
Estimated H-index: 3
(Copenhagen University Hospital)
+ 1 AuthorsInge Nordgaard-Lassen10
Estimated H-index: 10
(Copenhagen University Hospital)
Abstract Objective. Monitoring active ulcerative colitis (UC) is essential for making correct and timely treatment decisions. The current monitoring is based on symptom scores and biochemical markers, among which the role of fecal calprotectin (FC) is debated. The aims were to assess the development in FC during steroid treatment and to compare FC with symptom scores and biochemical markers. Material and methods. A prospective observational study, including 16 patients with active UC requiring h...
Cited By23
Newest
Published on Apr 2, 2019in Scientific Reports 4.01
Disha Tandon1
Estimated H-index: 1
(Tata Consultancy Services),
Mohammed Monzoorul Haque5
Estimated H-index: 5
(Tata Consultancy Services)
+ 4 AuthorsSharmila S. Mande10
Estimated H-index: 10
(Tata Consultancy Services)
Fructo-oligosaccharides (FOS), a prebiotic supplement, is known for its Bifidogenic capabilities. However, aspects such as effect of variable quantities of FOS intake on gut microbiota, and temporal dynamics of gut microbiota (transitioning through basal, dosage, and follow-up phases) has not been studied in detail. This study investigated these aspects through a randomized, double-blind, placebo-controlled, dose-response relationship study. The study involved 80 participants being administered ...
Published on Jun 26, 2019in Frontiers in Microbiology 4.26
Yanan Wang1
Estimated H-index: 1
,
Elissa Mortimer4
Estimated H-index: 4
+ 9 AuthorsGuy C. J. Abell22
Estimated H-index: 22
Published on Jun 6, 2019in Trends in Microbiology 11.97
Ryan Brewster4
Estimated H-index: 4
(Stanford University),
Fiona B Tamburini4
Estimated H-index: 4
(Stanford University)
+ 3 AuthorsAmi B. Bhatt23
Estimated H-index: 23
(Stanford University)
Descriptive and translational investigations into the human gut microbiome (GM) are rapidly expanding; however, studies are largely restricted to industrialized populations in the USA and Europe. Little is known about microbial variability and its implications for health and disease in other parts of the world. Populations in Africa are particularly underrepresented. What limited research has been performed has focused on a few subject domains, including the impact of long-term lifestyle and die...
Published on Jan 11, 2019
Ruth C. E. Bowyer2
Estimated H-index: 2
,
Matthew A. Jackson13
Estimated H-index: 13
+ 4 AuthorsClaire J. Steves17
Estimated H-index: 17
Socioeconomic inequalities in health and mortality are well established, but the biological mechanisms underlying these associations are less understood. In parallel, the gut microbiome is emerging as a potentially important determinant of human health, but little is known about its broader environmental and social determinants. We test the association between gut microbiota composition and individual- and area-level socioeconomic factors in a well-characterized twin cohort. In this study, 1672 ...
Published on Dec 1, 2018in BMC Oral Health 2.05
Federico Mussano14
Estimated H-index: 14
(UNITO: University of Turin),
Ilario Ferrocino17
Estimated H-index: 17
(UNITO: University of Turin)
+ 4 AuthorsStefano Carossa17
Estimated H-index: 17
(UNITO: University of Turin)
Background Apical periodontitis includes periapical granulomas and radicular cysts, which are histologically distinguished by the absence and the presence of an epithelial lining, respectively. The main cause of apical periodontitis is the bacterial colonization of the root canal space. This research aimed at assessing whether and how periapical granulomas and radicular cysts differ in terms of microbiota using high throughput amplicon target sequencing (HTS) techniques.
Published on Aug 9, 2018in Nutrients 4.17
Tiehua Zhang1
Estimated H-index: 1
,
Yang Yang1
Estimated H-index: 1
+ 2 AuthorsChanghui Zhao6
Estimated H-index: 6
With the rapid development of modern society, many chronic diseases are increasing including diabetes, obesity, cardiovascular diseases, etc., which further cause an increased death rate worldwide. A high caloric diet with reduced natural polysaccharides, typically indigestible polysaccharides, is considered a health risk factor. With solid evidence accumulating that indigestible polysaccharides can effectively prevent and/or ameliorate symptoms of many chronic diseases, we give a narrative revi...
Published on Aug 7, 2018in Frontiers in Microbiology 4.26
Zhanshan (Sam) Ma2
Estimated H-index: 2
(KIZ: Kunming Institute of Zoology),
Lianwei Li3
Estimated H-index: 3
(KIZ: Kunming Institute of Zoology),
Wendy Li (KIZ: Kunming Institute of Zoology)
A human body hosts a relatively independent microbiome including five major regional biomes (i.e., airway, oral, gut, skin, and urogenital). Each of them may possess different regional characteristics with important implications to our health and diseases (i.e., so-termed microbiome associated diseases). Nevertheless, these regional microbiomes are connected with each other through diffusions and migrations. Here, we investigate the within-body (intra-individual) distribution feature of microbio...
Published in bioRxiv
Angela C. Poole12
Estimated H-index: 12
(Cornell University),
Julia K. Goodrich18
Estimated H-index: 18
(Cornell University)
+ -3 AuthorsLynn M. Johnson2
Estimated H-index: 2
(Cornell University)
Host genetic variation influences the composition of the human microbiome. While studies have focused on associations between the microbiome and single nucleotide polymorphisms in genes, their copy number (CN) can also vary. Here, in a study of human subjects including a 2-week standard diet, we relate oral and gut microbiome to CN at the AMY1 locus, which encodes the gene for salivary amylase, active in starch degradation. We show that although diet standardization drove gut microbiome converge...
Published on Feb 1, 2018in Journal of Nutrition 4.42
Sophia E. Agapova6
Estimated H-index: 6
(WashU: Washington University in St. Louis),
Kevin B. Stephenson7
Estimated H-index: 7
(WashU: Washington University in St. Louis)
+ 6 AuthorsMark J. Manary44
Estimated H-index: 44
(UNIMA: University of Malawi)
Published on Jan 1, 2018
Fiona C. Malcomson4
Estimated H-index: 4
(Newcastle University),
John C. Mathers61
Estimated H-index: 61
(Newcastle University)
The ageing trajectory is plastic and can be slowed down by lifestyle factors, including good nutrition, adequate physical activity and avoidance of smoking. In humans, plant-based diets such as the Mediterranean dietary pattern are associated with healthier ageing and lower risk of age-related disease, whereas obesity accelerates ageing and increases the likelihood of most common complex diseases including CVD, T2D, dementia, musculoskeletal diseases and several cancers. As yet, there is only we...