Cardiac conditioning: a review of evolving strategies to reduce ischaemia-reperfusion injury

Acute ST-elevation myocardial infarction (STEMI) is characterised by unpredictable epicardial artery occlusion. The myocardium supplied by the vessel is rendered ischaemic and depending upon the degree of ischaemia and its duration, can be irreversibly injured, leading to necrotic cell death and myocardial infarction. With the recognition that restoration of blood flow to ischaemic myocardium can salvage ischaemic tissue before it is...