(Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation

Volume: 16, Issue: 9, Pages: 1114 - 1130
Published: Sep 1, 2015
Abstract
Mutations in PINK1 and PARKIN cause recessive, early-onset Parkinson's disease (PD). Together, these two proteins orchestrate a protective mitophagic response that ensures the safe disposal of damaged mitochondria. The kinase PINK1 phosphorylates ubiquitin (Ub) at the conserved residue S65, in addition to modifying the E3 ubiquitin ligase Parkin. The structural and functional consequences of Ub phosphorylation (pS65-Ub) have already been...
Paper Details
Title
(Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation
Published Date
Sep 1, 2015
Volume
16
Issue
9
Pages
1114 - 1130
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