Open flow microperfusion: pharmacokinetics of human insulin and insulin detemir in the interstitial fluid of subcutaneous adipose tissue

Aims To compare the time profile of insulin detemir and human insulin concentrations in the interstitial fluid ( ISF ) of subcutaneous adipose tissue during constant i.v. infusion and to investigate the relationship between the pharmacokinetics of both insulin molecules in plasma and the ISF of subcutaneous adipose tissue. Methods During a 6‐h hyperinsulinaemic–euglycaemic clamp (plasma glucose level 8 mmol/l) human insulin (21 and 42...