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Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis

Published on Mar 18, 2014in Annals of Internal Medicine19.315
· DOI :10.7326/M13-1788
Rajiv Chowdhury24
Estimated H-index: 24
,
Rajiv Chowdhury52
Estimated H-index: 52
+ 11 AuthorsEmanuele Di Angelantonio54
Estimated H-index: 54
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Abstract
Primary Funding Source: British Heart Foundation, Medical Research Council, Cambridge National Institute for Health Research Biomedical Research Centre, and Gates Cambridge.
  • References (44)
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were 1.06 (CI, 0.86 to 1.30), 1.06 (CI, 0.97 to 1.17), 0.84 (CI, 0.63 to 1.11), 0.94 (CI, 0.84 to 1.06), and 1.05 (CI, 0.76 to 1.44), respectively. There was heterogeneity of the associations among individual circulating fatty acids and coronary disease. In randomized, controlled trials, relative risks for coronary disease were 0.97 (CI, 0.69 to 1.36) for -linolenic, 0.94 (CI, 0.86 to 1.03) for long-chain -3 polyunsaturated, and 0.89 (CI, 0.71 to 1.12) for -6 polyunsaturated fatty acid supplemen...
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. Subgroup analyses were performed for the presence of blinding, the prevention settings, and patients with implantable cardioverter-defibrillators, and meta-regression analyses were performed for the omega-3 dose. A statistical significance threshold of .0063 was assumed after adjustment for multiple comparisons. Data Synthesis Of the 3635 citations retrieved, 20 studies of 68 680 patients were included, reporting 7044 deaths, 3993 cardiac deaths, 1150 sudden deaths, 1837 myocardial infarctions...
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