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Discrimination Between Obesity and Insulin Resistance in the Relationship With Adiponectin

Published on Mar 1, 2004in Diabetes7.20
· DOI :10.2337/diabetes.53.3.585
Fahim Abbasi47
Estimated H-index: 47
,
James Chu18
Estimated H-index: 18
+ 4 AuthorsPeter D. Reaven49
Estimated H-index: 49
Cite
Abstract
Insulin resistance and obesity are both associated with lower plasma adiponectin concentrations. Since insulin resistance and obesity are related, the extent to which the association of adiponectin with insulin resistance is dependent on its relationship with obesity is unclear. To address this issue, fasting plasma adiponectin concentrations were measured in 60 nondiabetic subjects, stratified into four equal groups on the basis of both their degree of adiposity and insulin resistance. Insulin resistance was quantified by determining the steady-state plasma glucose (SSPG) concentration in response to an infusion of octreotide, glucose, and insulin, and degree of adiposity was assessed by BMI. Subjects were defined as obese (BMI ≥30.0 kg/m 2 ) or nonobese ( 2 ) and as either insulin sensitive (SSPG 190 mg/dl). Insulin-resistant subjects had significantly ( P
  • References (36)
  • Citations (213)
Cite
References36
Newest
Published on Mar 1, 2004in Metabolism-clinical and Experimental6.51
Fahim Abbasi47
Estimated H-index: 47
(Stanford University),
Cindy Lamendola31
Estimated H-index: 31
(Stanford University)
+ 3 AuthorsPeter D. Reaven49
Estimated H-index: 49
Abstract Plasma adiponectin concentrations were measured before and after moderate weight loss in 20 obese women, divided at baseline into insulin-resistant (IR) and insulin-sensitive (IS) subgroups on the basis of their steady-state plasma glucose (SSPG) concentration at the end of a 180-minute infusion of octreotide, glucose, and insulin. The groups were similar in age and body weight and lost comparable amounts of weight (8 to 9 kg) during the weight loss period. Fasting plasma insulin and SS...
Published on Jun 1, 2003in Nature43.07
Toshimasa Yamauchi62
Estimated H-index: 62
(UTokyo: University of Tokyo),
Junji Kamon19
Estimated H-index: 19
(UTokyo: University of Tokyo)
+ 23 AuthorsMasaki Tsunoda14
Estimated H-index: 14
Corrigendum (2004) Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30)1,2,3,4 is a hormone secreted by adipocytes that acts as an antidiabetic5,6,7,8,9,10,11,12 and anti-atherogenic8,12,13 adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes2. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice5,6,7. Conversely, adiponectin-deficient mice exh...
Published on Feb 1, 2003in Biochemical and Biophysical Research Communications2.71
Mathias Fasshauer52
Estimated H-index: 52
(Leipzig University),
Susan Kralisch30
Estimated H-index: 30
(Leipzig University)
+ 4 AuthorsRalf Paschke57
Estimated H-index: 57
(Leipzig University)
Recently, it has been shown that adiponectin is an important insulin-sensitizing fat-derived protein which is downregulated in insulin resistance and obesity, and replenishment of which improves insulin sensitivity. In contrast, interleukin (IL)-6 appears as an adipocytokine serum concentrations of which are elevated in these states. However, it has not been determined whether IL-6 might impact on expression and secretion of adiponectin. To clarify this, 3T3-L1 adipocytes were treated with diffe...
Published on Feb 1, 2003in Diabetes7.20
Otto Tschritter32
Estimated H-index: 32
,
Andreas Fritsche71
Estimated H-index: 71
+ 7 AuthorsMichael Stumvoll85
Estimated H-index: 85
In animals, the adipocyte-derived hormone adiponectin has been shown to improve insulin sensitivity, a key factor in the pathogenesis of type 2 diabetes. In Pima Indians, high plasma adiponectin levels are associated with increased insulin sensitivity and reduced risk of type 2 diabetes. It is unclear whether this is also the case in white individuals and whether an additional beneficial effect on lipid metabolism exists. We therefore analyzed in nondiabetic individuals the associations between ...
Published on Jan 1, 2003in Pediatric Research2.88
Dan Nemet25
Estimated H-index: 25
,
Ping Wang1
Estimated H-index: 1
+ 4 AuthorsDan M. Cooper48
Estimated H-index: 48
Top of pageAbstract Recent evidence suggests a role for adipose derived cytokines (adipocytokines) such as tumor necrosis factor-α (TNF-α), IL-6, and the recently discovered adiponectin in the mechanism of impaired glucose regulation and atherosclerosis in adults. However, the relationship between adipocytokines and body composition, fasting insulin, and fitness is virtually unknown children. Fasting blood sampling was performed in 30 healthy, predominately Hispanic- and Asian-American children ...
Published on Dec 3, 2002in Circulation23.05
Tracey McLaughlin40
Estimated H-index: 40
,
Fahim Abbasi47
Estimated H-index: 47
+ 4 AuthorsPeter D. Reaven49
Estimated H-index: 49
Background— Plasma C-reactive protein (CRP) concentrations are increased in obese and/or hyperinsulinemic individuals. The goal of this study was to determine if the relation between insulin resistance and CRP was independent of obesity. Methods and Results— Plasma CRP concentrations were measured before and after 3 months of calorie restriction in 38 healthy, obese women. Steady-state plasma glucose (SSPG) concentration during a 180-minute infusion of octreotide, glucose, and insulin was used t...
Published on Dec 1, 2002in The Journal of Clinical Endocrinology and Metabolism5.61
Hiroyuki Motoshima24
Estimated H-index: 24
,
Xiangdong Wu16
Estimated H-index: 16
+ 5 AuthorsBarry J. Goldstein53
Estimated H-index: 53
Adiponectin is an adipocyte-derived plasma protein with insulin-sensitizing and antiatherosclerotic properties. Because adipose tissue depots differ in the strength of their association with the adverse metabolic consequences of obesity, we studied the secretion of adiponectin in vitro from paired samples of isolated human omental and sc adipocytes and its regulation by insulin and rosiglitazone. Cells were incubated for 12 or 24 h with and without treatment with 100 nm insulin, 8 μm rosiglitazo...
Published on Nov 1, 2002in Hormone and Metabolic Research2.42
Matthias Möhlig40
Estimated H-index: 40
,
Uta Wegewitz4
Estimated H-index: 4
+ 4 AuthorsJ. Spranger27
Estimated H-index: 27
Insulin resistance and hyperinsulinemia are known atherosclerosis risk factors. The association between adiponectin plasma levels and obesity, insulinemia, and atherosclerosis has been shown. Thus, adiponectin may be a link between hyperinsulinemia and vascular disease. In vitro data demonstrated a reduction of adiponectin expression by insulin. However, it is still unclear whether insulin regulates adiponectinemia in vivo in humans. Five healthy male volunteers were studied. Circulating adipone...
Matthew W. Hulver32
Estimated H-index: 32
,
Donghai Zheng20
Estimated H-index: 20
+ 7 AuthorsG. Lynis Dohm44
Estimated H-index: 44
Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is alte...
Published on Oct 1, 2002in Diabetes7.20
Joseph G. Yu12
Estimated H-index: 12
,
Sandrine Javorschi1
Estimated H-index: 1
+ 4 AuthorsJerrold M. Olefsky106
Estimated H-index: 106
The insulin-sensitizing effects of thiazolidinediones are thought to be mediated through peroxisome proliferator-activated receptor-γ, a nuclear receptor that is highly abundant in adipose tissue. It has been reported that adipocytes secrete a variety of proteins, including tumor necrosis factor-α, resistin, plasminogen activator inhibitor-1, and adiponectin. Adiponectin is a fat cell-secreted protein that has been reported to increase fat oxidation and improve insulin sensitivity. Our aim was t...
Cited By213
Newest
Published on 2019in Domestic Animal Endocrinology2.30
Alberto Muñoz-Prieto2
Estimated H-index: 2
(University of Murcia),
Silvia Martínez-Subiela23
Estimated H-index: 23
(University of Murcia)
+ 2 AuthorsAsta Tvarijonaviciute18
Estimated H-index: 18
(University of Murcia)
Abstract Adiponectin (ADP) is an adipokine secreted by adipose tissue with anti-inflammatory, anti-atherogenic and anti-diabetic properties. In human serum, it is presented as three different forms: low-molecular-weight (LMW), medium-molecular-weight (MMW) and high-molecular-weight (HMW). HMW isomer is the most active form of adiponectin and is more closely related with obesity-induced insulin resistance and metabolic syndrome than total adiponectin. Selective protease treatment can be used in h...
Published on Sep 16, 2019in Journal of Clinical Investigation12.28
Gordon I. Smith3
Estimated H-index: 3
,
Bettina Mittendorfer47
Estimated H-index: 47
,
Samuel Klein89
Estimated H-index: 89
Published on 2019in Research in Veterinary Science1.75
Alberto Muñoz-Prieto2
Estimated H-index: 2
(University of Murcia),
Silvia Martínez-Subiela23
Estimated H-index: 23
(University of Murcia)
+ 1 AuthorsAsta Tvarijonaviciute18
Estimated H-index: 18
(University of Murcia)
Abstract Adiponectin is an adipokine that exerts insulin-sensitizing and antiinflammatory properties. The aim of this study was to develop and validate a new heterologous ultrasensitive assay based on amplified luminescent technology for adiponectin determination in serum and saliva of dogs. A complete analytical validation of the assay was made in these fluids, and also this assay was applied to quantify adiponectin in serum and saliva of obese and lean dogs and dogs with leishmaniosis. These c...
Published on Dec 1, 2018in BMC Genomics3.50
Baojun Li2
Estimated H-index: 2
(Shanxi Agricultural University),
Liying Qiao4
Estimated H-index: 4
(Shanxi Agricultural University)
+ 6 AuthorsWenzhong Liu4
Estimated H-index: 4
(Shanxi Agricultural University)
The level of fat deposition in carcass is a crucial factor influencing meat quality. Guangling Large-Tailed (GLT) and Small-Tailed Han (STH) sheep are important local Chinese fat-tailed breeds that show distinct patterns of fat depots. To gain a better understanding of fat deposition, transcriptome profiles were determined by RNA-sequencing of perirenal, subcutaneous, and tail fat tissues from both the sheep breeds. The common highly expressed genes (co-genes) in all the six tissues, and the gen...
Published on Nov 6, 2018in PLOS ONE2.78
Konstantinos A. Toulis15
Estimated H-index: 15
(University of Birmingham),
Chao Qiang Jiang4
Estimated H-index: 4
+ 4 AuthorsG. Neil Thomas4
Estimated H-index: 4
(University of Birmingham)
Background To evaluate the additional discriminatory performance of adiponectin, leptin, and their ratio in the identification of impaired glucose tolerance (IGT) in men and women without diabetes on top of conventional risk factors. Methods & results A total of 698 subjects underwent an oral glucose tolerance test (oGTT) and adipocytokine measurements. A comprehensive stepwise selection procedure was performed, followed by c-statistics and integrated discrimination improvement (IDI) analysis. I...
Panagiota Papargyri (UoA: National and Kapodistrian University of Athens), Evangelia Zapanti5
Estimated H-index: 5
(Alexandra Hospital)
+ 3 AuthorsGeorge Mastorakos46
Estimated H-index: 46
(UoA: National and Kapodistrian University of Athens)
ABSTRACTIntroduction: In the human organism, a constant interplay exists between the stress system [which includes the activity of the hypothalamic-pituitary-adrenal (HPA) axis] and the adipose tissue. This interplay is mediated by hormones of the HPA axis such as corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and glucocorticoids (GCs) and adipokines secreted by the adipose tissue.Areas covered: In this critical review, the bi-directional interactions between HPA axis ...
Published on Oct 2, 2018in Frontiers in Endocrinology3.63
Yeyi Zhu11
Estimated H-index: 11
(KP: Kaiser Permanente),
Monique M. Hedderson27
Estimated H-index: 27
(KP: Kaiser Permanente)
+ 2 AuthorsAssiamira Ferrara46
Estimated H-index: 46
(KP: Kaiser Permanente)
Background: Liver enzymes may be implicated in glucose homeostasis; liver enzymes progressively change during pregnancy but longitudinal data during pregnancy in relation to insulin resistance and gestational diabetes (GDM) risk are lacking. We investigated longitudinal associations of γ-glutamyl transferase (GGT) and alanine aminotransferase (ALT) with insulin secretion and resistance markers across early to mid-pregnancy and subsequent GDM risk. Methods: Within the prospective Pregnancy Enviro...
Published on Sep 19, 2018in Frontiers in Physiology3.20
Zhengtao Liu5
Estimated H-index: 5
(ZJU: Zhejiang University),
Shuheng Liang1
Estimated H-index: 1
(Boston Children's Hospital)
+ 3 AuthorsAdil Mardinoglu27
Estimated H-index: 27
(Chalmers University of Technology)
Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1248 and 6020 subjects, respectively. Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve=0.81, ...
Published on Dec 1, 2017in Lipids in Health and Disease2.65
Zhonge Chen1
Estimated H-index: 1
(Graduate School USA),
Rong Yu1
Estimated H-index: 1
(NCU: Nanchang University)
+ 2 AuthorsShuishan Zhu1
Estimated H-index: 1
(NCU: Nanchang University)
Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of diseases, including simple steatosis, nonalcoholic steatohepatitis (NASH), liver cirrhosis and hepatocellular carcinoma. Lipotoxicity, insulin resistance (IR) and inflammation are involved in the disease process. Lipotoxicity promotes inflammation and IR, which in turn, increase adipocyte lipolysis and exacerbates lipotoxicity. Furthermore, IR and inflammation form a vicious circle, with each condition promoting the other and accel...
Published on Jun 1, 2017in Medicine1.87
Yiping Li6
Estimated H-index: 6
,
Chuanyin Li1
Estimated H-index: 1
+ 7 AuthorsChunjie Xiao2
Estimated H-index: 2
View next paperParadoxical decrease of an adipose-specific protein, adiponectin, in obesity.