Th17 Cells Induce Th1-Polarizing Monocyte-Derived Dendritic Cells
Abstract
In chronically inflamed tissues, such as those affected by autoimmune disease, activated Th cells often colocalize with monocytes. We investigate in this study how murine Th cells influence the phenotype and function of monocytes. The data demonstrate that Th1, Th2, and Th17 subsets promote the differentiation of autologous monocytes into MHC class II+, CD11b+, CD11c+ DC that we call DCTh. Although all Th subsets induce the formation of DCTh,...
Paper Details
Title
Th17 Cells Induce Th1-Polarizing Monocyte-Derived Dendritic Cells
Published Date
Aug 1, 2013
Journal
Volume
191
Issue
3
Pages
1175 - 1187
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