CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems

Volume: 69, Issue: 1, Pages: 209 - 228
Published: Oct 21, 2015
Abstract
Prokaryotic CRISPR-Cas loci encode proteins that function as an adaptive immune system against infectious viruses and plasmids. Immunity is mediated by Cas nucleases and small RNA guides, which specify a cleavage site within the genome of the invader. In type II CRISPR-Cas systems, the RNA-guided Cas9 nuclease cleaves the DNA. Cas9 can be reprogrammed to create double-strand DNA breaks in the genomes of a variety of organisms, from bacteria to...
Paper Details
Title
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
Published Date
Oct 21, 2015
Volume
69
Issue
1
Pages
209 - 228
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