X. Rural Southern Japan

Published on Apr 1, 1970in Circulation23.054
· DOI :10.1161/01.CIR.41.4S1.I-101
Noboru Kimura6
Estimated H-index: 6
Ancel Keys71
Estimated H-index: 71
  • References (0)
  • Citations (20)
📖 Papers frequently viewed together
1 Author (Ancel Keys)
1,526 Citations
2 Authors (Kimura N, Keys A)
20 Citations
5 Authors (Christ Aravanis, ..., Ancel Keys)
36 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
Cited By20
#1Poonamjot Deol (UCR: University of California, Riverside)H-Index: 3
#2Jane R. Evans (UCR: University of California, Riverside)H-Index: 4
Last. Frances M. Sladek (UCR: University of California, Riverside)H-Index: 38
view all 7 authors...
The obesity epidemic in the U.S. has led to extensive research into potential contributing dietary factors, especially fat and fructose. Recently, increased consumption of soybean oil, which is rich in polyunsaturated fatty acids (PUFAs), has been proposed to play a causal role in the epidemic. Here, we designed a series of four isocaloric diets (HFD, SO-HFD, F-HFD, F-SO-HFD) to investigate the effects of saturated versus unsaturated fat, as well as fructose, on obesity and diabetes. C57/BL6 mal...
29 CitationsSource
A number of epidemiological/observational studies, as well as large-scale randomized intervention studies, have been conducted to provide evidence for the efficacy of ω-3 fatty acids against atherosclerotic diseases. Currently, ω-3 fatty acids are commercially available in many parts of the world containing the same active ingredients as Lotriga® (ω-3-acid ethyl esters 90 [O3AE highly concentrated ω-3 fatty acid ethyl esters, consisting of eicosapentaenoic acid-ethyl ester and docosahexaenoic ac...
6 CitationsSource
#1Paul Rankin (Avondale College)H-Index: 6
#1Federico Soriguer (ISCIII: Carlos III Health Institute)H-Index: 29
#2Eva García-Escobar (ISCIII: Carlos III Health Institute)H-Index: 14
Last. Gemma Rojo-Martínez (ISCIII: Carlos III Health Institute)H-Index: 31
view all 7 authors...
The Spanish paradox is a phenomenon observed in Spain and some other Mediterranean countries by which the cardiovascular morbidity and mortality levels are dissociated from their cardiovascular risk factors. The Mediterranean diet has been proposed as the main reason for this dissociation, but dietary changes themselves are not enough to explain this situation. It has been recently discovered that Stearoil-CoA desaturase (SCD) is involved in the dissociation between a favourable atherogenic meta...
13 CitationsSource
#1Shilpa N. Bhupathiraju (NU: Northeastern University)H-Index: 24
#2Katherine L. Tucker (NU: Northeastern University)H-Index: 87
Abstract Diet is a key modifiable risk factor in the prevention and risk reduction of coronary heart disease (CHD). Results from the Seven Countries Study in the early 1970s spurred an interest in the role of single nutrients such as total fat in CHD risk. With accumulating evidence, we have moved away from a focus on total fat to the importance of considering the quality of fat. Recent meta-analyses of intervention studies confirm the beneficial effects of replacing saturated fat with polyunsat...
159 CitationsSource
#1Andrew L. Milkowski (UW: University of Wisconsin-Madison)H-Index: 10
#2Harsha K. Garg (University of Texas Health Science Center at Houston)H-Index: 11
Last. Nathan S. Bryan (University of Texas Health Science Center at Houston)H-Index: 38
view all 4 authors...
Abstract The discovery of the nitric oxide (NO) pathway in the 1980s represented a critical advance in understanding cardiovascular disease, and today a number of human diseases are characterized by NO insufficiency. In the interim, recent biomedical research has demonstrated that NO can be modulated by the diet independent of its enzymatic synthesis from l -arginine, e.g., the consumption of nitrite- and nitrate-rich foods such as fruits, leafy vegetables, and cured meats along with antioxidant...
80 CitationsSource
#1Betsy B. Dokken (UA: University of Arizona)H-Index: 10
• The role of dietary fat in health and disease is controversial as fatty acids act as signaling molecules in a variety of metabolic pathways and dietary fat has a role in both the etiology and prevention of insulin resistance and type 2 diabetes.
#1Kerstin Dudas (University of Gothenburg)H-Index: 7
Aim: To investigate how risk factors predict manifestations in coronary heart disease (CHD), and trends in short-term and long-term survival including trends in out-of-hospital mortality. Populations and methods: In the fi rst study 7388 men aged 47 to 55 and free of previous acute myocardial infarction (AMI) or stroke were investigated during 28 years’ follow-up. In the second and third study we created a record linked database from the Swedish hospital discharge and death registries documentin...
#1Hirotsugu Ueshima (Shiga University of Medical Science)H-Index: 70
Japan's age-adjusted rate for mortality from stroke increased after the Second World War until 1965 and then showed a significant decline until 1990; however, the age-adjusted rate for mortality from all heart disease and coronary heart disease (CHD) increased until 1970 and then declined slowly. A puzzling question is why the rate of mortality from CHD declined in spite of an increase in serum total cholesterol level following an increase in fat consumption.It was confirmed that CHD incidence w...
194 CitationsSource
#1Zeynep Öztürk (Istanbul University)H-Index: 6
#2Hüseyin Sönmez (Istanbul University)H-Index: 11
Last. E. Kökoglu (Istanbul University)H-Index: 13
view all 9 authors...
ABSTRACTHigh serum total cholesterol concentration has been strongly connected with atherosclerosis in numerous studies. Being the main carrier of cholesterol in blood, low-density lipoprotein (LDL) is also the principal lipoprotein causing atherosclerosis. Sialic acids are a family of amino sugars that are commonly found as terminal oligosaccharide residues on glycoproteins and are sialylated on their apolipoprotein and glycolipid constituents. In several studies, it was demonstrated that LDL h...
4 CitationsSource