A Single Amino Acid Substitution in HIV-1 Reverse Transcriptase Significantly Reduces Virion Release
Abstract
HIV-1 protease (PR) mediates the proteolytic processing of virus particles during or after virus budding. PR activation is thought to be triggered by appropriate Gag-Pol/Gag-Pol interaction; factors affecting this interaction either enhance or reduce PR-mediated cleavage efficiency, resulting in markedly reduced virion production or the release of inadequately processed virions. We previously showed that a Gag-Pol deletion mutation involving the...
Paper Details
Title
A Single Amino Acid Substitution in HIV-1 Reverse Transcriptase Significantly Reduces Virion Release
Published Date
Jan 15, 2010
Journal
Volume
84
Issue
2
Pages
976 - 982
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