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p53-dependent antiproliferative and antitumor effect of novel alkyl series of diorganotin(IV) compounds

Published on Aug 1, 2009in Investigational New Drugs 2.66
· DOI :10.1007/s10637-008-9176-6
Biplob Koch17
Estimated H-index: 17
(NEHU: North Eastern Hill University),
Tushar S. Basu Baul23
Estimated H-index: 23
(NEHU: North Eastern Hill University),
Anupam Chatterjee17
Estimated H-index: 17
(NEHU: North Eastern Hill University)
Cite
Abstract
Purpose: A series of diorganotin(IV) dichloride complexes of N-(2-pyridylmethylene)arylamine (nitrogen-chelating ligands) have been synthesized and characterized. The present study was carried out to investigate the comparative anti-proliferative and anti-tumor effect of Me2SnCl2.L1 (OTC-1), Et2SnCl2.L2 (OTC-2) and nBu2SnCl.L2 (OTC-3) in combination with X-rays (1.5 Gy). Method: The cytotoxicity of these diorganotin(IV) compounds was studied in human peripheral lymphocytes and the antitumor activity was assessed in Dalton’s lymphoma cells. The involvement of proteins that regulate cell cycle and apoptosis was investigated to elucidate the mechanism of their action. Results: 5 mg kg−1 of OTC-3 showed better antiproliferative and antitumor activity than OTC-1 and OTC-2, both as alone or in combination with X-rays. The maximum enhancement of exchange aberrations and the level of p53 and p16 proteins were observed in the OTC-3 treated samples. Upregulated expression of p53 caused a significant down-regulated transcriptionally repression of Survivin in OTC-3 treated human lymphocytes. Conclusion: It could be possible that after treatment with either OTC-3 alone or in combination with X-rays the Dalton’s lymphoma cells may die apoptotically after inducing initial delay in cell cycle and thereby survivality of mouse bearing Dalton’s Lymphoma cells was increased significantly.
  • References (24)
  • Citations (11)
Cite
References24
Newest
Published on May 1, 2008in Journal of Applied Toxicology 3.06
Biplob Koch17
Estimated H-index: 17
(NEHU: North Eastern Hill University),
Tushar S. Basu Baul23
Estimated H-index: 23
(NEHU: North Eastern Hill University),
Anupam Chatterjee17
Estimated H-index: 17
(NEHU: North Eastern Hill University)
Diorganotin(IV) compounds, R2SnCl2 are often tetrahedral, and structurally resemble the active platinum compounds, i.e. cisplatin, and consequently a large number of such complexes have been tested for antitumor activity. A structural correlation with biological activity for diorganotin(IV) complexes has shown that active species are associated with complexes having Sn–N bonds longer than 2.39 A which in turn determines the formation of a tin–DNA complex. In view of these, a series of diorganoti...
Published on Dec 20, 2005
Marcel Gielen34
Estimated H-index: 34
(Vrije Universiteit Brussel),
Edward R. T. Tiekink45
Estimated H-index: 45
(NUS: National University of Singapore)
Published on Dec 1, 2003in International Journal of Radiation Biology 2.27
Loredana Bassi6
Estimated H-index: 6
,
M. Carloni3
Estimated H-index: 3
+ 2 AuthorsF. Palitti9
Estimated H-index: 9
Purpose: To investigate whether unstable types of chromosomal aberrations are more effective in priming apoptotic cell death in comparison with stable ones. Also, to highlight the phase of the cell cycle at which apoptosis occurs and the mechanism of its execution.Materials and methods: G0 human peripheral blood lymphocytes were X‐irradiated in the presence or absence of the repair inhibitor cytosine arabinoside (Ara‐C). After irradiation, the lymphocytes were analysed for induction of dicentric...
Published on Jan 1, 2003in International Journal of Radiation Biology 2.27
J.D. Harrison10
Estimated H-index: 10
(National Radiological Protection Board),
Colin R. Muirhead16
Estimated H-index: 16
(National Radiological Protection Board)
Purpose: To compare quantitative estimates of lifetime cancer risk in humans for exposures to internally deposited radionuclides and external radiation. To assess the possibility that risks from radionuclide exposures may be underestimated.Materials and methods: Risk estimates following internal exposures can be made for a small number of alpha-particle-emitting nuclides. (1) Lung cancer in underground miners exposed by inhalation to radon-222 gas and its short-lived progeny. Studies of resident...
Published on Jan 1, 2003in Acta Oncologica 3.30
Nina Einhorn21
Estimated H-index: 21
(KI: Karolinska Institutet),
Claes G. Tropé56
Estimated H-index: 56
+ 3 AuthorsEva Cavallin-Ståhl37
Estimated H-index: 37
(Lund University)
A systematic review of radiation therapy trials in several tumour types was performed by The Swedish Council of Technology Assessment in Health Care (SBU). The procedures for evaluation of the scientific literature are described separately (Acta Oncol 2003; 42: 357-365). This synthesis of the literature on radiation therapy for cervical cancer is based on data from 1 meta-analysis and 34 randomized trials. In total, 35 scientific articles are included, involving 7952 patients. The results were c...
Published on Feb 1, 2002in Journal of Biological Chemistry
William H. Hoffman1
Estimated H-index: 1
(Fox Chase Cancer Center),
Siham Biade3
Estimated H-index: 3
(Fox Chase Cancer Center)
+ 2 AuthorsMaureen E. Murphy19
Estimated H-index: 19
(Fox Chase Cancer Center)
Abstract Survivin is a member of the inhibitor of apoptosis family. This apoptosis inhibitor also has an evolutionarily conserved role as a mitotic spindle checkpoint protein. Previous studies on p53-repressed genes have implicated several genes involved in the G2/M transition of the cell cycle as targets of negative regulation by p53. However, few targets of p53 repression that are anti-apoptotic have been identified. This study identifies the anti-apoptotic survivin gene as a p53-repressed gen...
Christine Syng-ai3
Estimated H-index: 3
(NEHU: North Eastern Hill University),
Tushar S. Basu Baul23
Estimated H-index: 23
(NEHU: North Eastern Hill University),
Anupam Chatterjee17
Estimated H-index: 17
(NEHU: North Eastern Hill University)
Abstract Organotin compounds are organometallic compounds showing various toxicological properties. Several organotin compounds also showed an antineoplastic effect. However, their relative mutagenic potential is not well established. In this study Et 2 SnCl 2 ·L [L= N -(2-pyridylmethylene)-4-toluidine] (OTC) has been subjected to investigation for its cytotoxic effect in mouse bone marrow cells (BMCs) and human peripheral blood lymphocyte cells (HPBLs). The SnN bond in OTC is 2.46 A which is g...
Published on Jan 1, 2002in Coordination Chemistry Reviews 13.48
L. Pellerito22
Estimated H-index: 22
(University of Palermo),
László Nagy24
Estimated H-index: 24
(University of Szeged)
Abstract The organotin(IV) cations form complexes with ligands containing {O}, {N}, {S}, or {phosphorus(O)} donor atoms with various composition and stability. The emergence of new experimental techniques (EXAFS, multinuclear 1 H-, 13 C-, 119 Sn-NMR, 119 Sn Mossbauer, etc., spectroscopic techniques) provided useful information about the structure and stabilities of the complexes formed. We reviewed the literature on these type of complexes taking into account the biological aspects of the comple...
Published on Oct 1, 1999in Human & Experimental Toxicology 2.17
A De Santiago1
Estimated H-index: 1
,
Miguel Aguilar-Santelises17
Estimated H-index: 17
Organotin compounds (OTC) are organometallic compounds with vast industrial and agriculture applications that give rise to ubiquitous environmental contamination. OTC are immunotoxic, but most studies have been performed in rodents and almost exclusively focused on T cell immunity. Humans can be exposed to OTC by inhalation, absorption, and consumption of contaminated food and water. To analyse the effects of OTC in human immune tissue, we isolated B cells from tonsils and exposed them to five O...
Published on Apr 1, 1999in Toxicology and Applied Pharmacology 3.58
Hélène Stridh6
Estimated H-index: 6
(KI: Karolinska Institutet),
Sten Orrenius119
Estimated H-index: 119
(KI: Karolinska Institutet),
Mark B. Hampton46
Estimated H-index: 46
Organotin compounds such as tributyltin (TBT) and triphenyltin (TPT) can kill target cells by triggering apoptosis. The mechanism by which these environmental toxicants activate the apoptotic program is currently unclear. We have studied the effect of TBT and TPT in the human Hut-78 and Jurkat T-lymphocyte cell lines. Within 1 h there was a 30-fold increase in caspase activity, as measured by the cleavage of the fluorescent peptide DEVD-AMC. Morphological changes characteristic of apoptosis, suc...
Cited By11
Newest
Published on Feb 1, 2015in Sensors and Actuators B-chemical 6.39
Ajit Kumar Mahapatra18
Estimated H-index: 18
(Indian Institute of Engineering Science and Technology, Shibpur),
Rajkishor Maji11
Estimated H-index: 11
(Indian Institute of Engineering Science and Technology, Shibpur)
+ 8 AuthorsChing Kheng Quah19
Estimated H-index: 19
(Universiti Sains Malaysia)
Abstract A novel N,O-chelated perimidine–boron complex (PB) has been synthesized and characterized. Synthesized complex PB, behave as a colorimetric and fluorometric probe for selective and sensitive detection of F − . Compound PB reacts with fluoride ion in a 1:1 stoichiometry to afford for corresponding brightly fluorescent perimidine–boron difluoride (PBF) and its single crystal X-RD structure has been established. Chelated features and electronic properties of the PB and PBF have been comput...
Published on Jan 1, 2015in RSC Advances 3.05
Ajit Kumar Mahapatra18
Estimated H-index: 18
(Indian Institute of Engineering Science and Technology, Shibpur),
Kalipada Maiti13
Estimated H-index: 13
(Indian Institute of Engineering Science and Technology, Shibpur)
+ 4 AuthorsSrimanta Manna5
Estimated H-index: 5
(Indian Institute of Engineering Science and Technology, Shibpur)
An indole conjugated thiophene–pyridyl (ITP) sensor for cyanide has been synthesized and characterized using NMR and mass spectroscopy. The selectivity of ITP has been explored in aqueous solution, and the resulting ratiometric fluorescence response toward CN−, among 11 different anions, was studied. The complexation of ITP–CN has been addressed using HRMS, 1H-NMR, and UV-vis spectroscopy. ITP displays substantial dual changes in both its ratiometric emission and absorption spectra, exclusively ...
Published on Dec 1, 2014in Chemistry-an Asian Journal 3.70
Ajit Kumar Mahapatra18
Estimated H-index: 18
(Indian Institute of Engineering Science and Technology, Shibpur),
Kalipada Maiti13
Estimated H-index: 13
(Indian Institute of Engineering Science and Technology, Shibpur)
+ 4 AuthorsSabyasachi Sarkar27
Estimated H-index: 27
(Indian Institute of Engineering Science and Technology, Shibpur)
A new benzimidazole-spiropyran conjugate chemosensor molecule (BISP) has been synthesized and characterized by 1H NMR spectroscopy, mass spectrometry (ESI-MS), and elemental analysis. The two isomeric forms (BISPBIMC) were shown to be highly selective and sensitive to CN− among the ten anions studied in aqueous HEPES buffer, as shown by fluorescence and absorption spectroscopy and even by visual color changes, with a detection limit of 1.7 μM for BIMC. The reaction of CN− with BIMC was monitored...
Published on Mar 1, 2014in Applied Organometallic Chemistry 3.26
Rui Ge6
Estimated H-index: 6
(Shanxi Medical University),
Yi-Jie Wang1
Estimated H-index: 1
(Shanxi Medical University)
+ 4 AuthorsQingshan Li7
Estimated H-index: 7
(Shanxi Medical University)
Di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT) is an antitumor compound with high activity and relatively low bioavailability. In order to improve the pharmacokinetic characteristics and raise its therapeutic index, a liposome of DBDCT (DBDCT-L) was prepared for the first time. A study of the pharmacokinetics and tissue distribution after intravenous administration of DBDCT-L compared with free DBDCT to rats was investigated. DBDCT-L showed a slower clearance, increased half-time and a ...
Published on Jan 1, 2014in Dalton Transactions 4.05
Chunlin Ma14
Estimated H-index: 14
(Liaocheng University),
Shuang Cheng7
Estimated H-index: 7
(Liaocheng University)
+ 3 AuthorsShao-Liang Zhang6
Estimated H-index: 6
(Liaocheng University)
A new arenetelluronic triorganotin ester, namely (Me3Sn)4[o-Me-PhTe(μ-O)(OH)O2)]2 (1) has been prepared by the reaction of o-tolyltelluronic acid and Me3SnCl in the presence of potassium hydroxide. The complex was fully characterized by elemental analysis, FT-IR, NMR (1H, 13C, 119Sn) spectroscopy and X-ray crystallography. Structure analysis revealed that the complex crystallized as Sn4Te2 units and a 1D linear chain was formed by intermolecular C–H⋯O interactions. Cytotoxic assessments showed t...
Published on Oct 7, 2013in Inorganic Chemistry 4.85
Ajit Kumar Mahapatra18
Estimated H-index: 18
,
Saikat Kumar Manna12
Estimated H-index: 12
+ 1 AuthorsChitrangada Das Mukhopadhyay11
Estimated H-index: 11
A structurally characterized new oxo-chromene functionalized rhodamine derivative L1 exhibits high selectivity toward Sn4+ by forming a 1:1 complex, among other biologically important metal ions, as studied by fluorescence, absorption, and HRMS spectroscopy. Complexing with Sn4+ triggers the formation of a highly fluorescent ring-open form which is pink in color. The sensor shows extremely high fluorescence enhancement upon complexation with Sn4+, and it can be used as a “naked-eye” sensor. DFT ...
Published on Jan 1, 2013
H.-L. Seng (UM: University of Malaya), Edward R. T. Tiekink45
Estimated H-index: 45
(UM: University of Malaya)
Main-group element compounds were among the first developed in the modern era as pharmaceutical preparations for the treatment of a wide variety of human ailments; it is now recognized that many of these elements exist in traditional medicine of many societies, for example, arsenic. The use of main-group element compounds in contemporary medicine continues for the treatment of, for example, depression (Li), stomach ulcers (Bi), cancer (As and Ga), and leishmaniasis (Sb). Not surprisingly, new co...
Published on Sep 1, 2012in European Journal of Pharmaceutical Sciences 3.53
Apostolos Metsios9
Estimated H-index: 9
(UoI: University of Ioannina),
Ioannis I. Verginadis13
Estimated H-index: 13
(UoI: University of Ioannina)
+ 6 AuthorsSpyridon Karkabounas10
Estimated H-index: 10
(UoI: University of Ioannina)
Abstract Since the initial success of cisplatin, metal complexes and organometallic compounds have been gaining growing interest in cancer therapy. It is well known that organotin(IV) compounds display strong biological activity. The triorganotin compound [(C 6 H 5 ) 3 Sn(cmbzt)] (cmbzt = 5-chloro-2-mercaptobenzothiazole) (SnCMB), was tested for its antiproliferative and antitumour activities. Two sets of experimental procedures were followed: (1) In vitro and ex vivo procedures included the stu...
Published on May 27, 2011in Materials 2.97
Michael R. Roner19
Estimated H-index: 19
,
Charles E. Carraher24
Estimated H-index: 24
(FAU: Florida Atlantic University)
+ 1 AuthorsGirish Barot11
Estimated H-index: 11
(BU: Boston University)
Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very ...