X-ray Crystallographic Studies of Proteins

Following the dramatic impact of the first protein structure determinations, the field of macromolecular crystallography has expanded with ever-increasing rapidity. In many cases the techniques used are the same as those pioneered by Perutz and Kendrew and their disciples, but the preoccupation has shifted from methods to results. The first glimpses of protein architecture, provided by myoglobin (1) and hemoglobin (2), showed that proteins with...