Review paper

The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity

Volume: 3, Issue: 3, Pages: 703 - 729
Published: Sep 10, 2015
Abstract
Indoleamine 2, 3-dioxygenase (IDO) is the first and rate limiting catabolic enzyme in the degradation pathway of the essential amino acid tryptophan. By cleaving the aromatic indole ring of tryptophan, IDO initiates the production of a variety of tryptophan degradation products called "kynurenines" that are known to exert important immuno-regulatory functions. Because tryptophan must be supplied in the diet, regulation of tryptophan catabolism...
Paper Details
Title
The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity
Published Date
Sep 10, 2015
Journal
Volume
3
Issue
3
Pages
703 - 729
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