ESX‐1‐mediated translocation to the cytosol controls virulence of mycobacteria
Abstract
Mycobacterium species, including Mycobacterium tuberculosis and Mycobacterium leprae, are among the most potent human bacterial pathogens. The discovery of cytosolic mycobacteria challenged the paradigm that these pathogens exclusively localize within the phagosome of host cells. As yet the biological relevance of mycobacterial translocation to the cytosol remained unclear. In this current study we used electron microscopy techniques to...
Paper Details
Title
ESX‐1‐mediated translocation to the cytosol controls virulence of mycobacteria
Published Date
May 8, 2012
Journal
Volume
14
Issue
8
Pages
1287 - 1298
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History