Original paper
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
Abstract
Cytosine methylation is required for mammalian development and is often perturbed in human cancer. To determine how this epigenetic modification is distributed in the genomes of primary and transformed cells, we used an immunocapturing approach followed by DNA microarray analysis to generate methylation profiles of all human chromosomes at 80-kb resolution and for a large set of CpG islands. In primary cells we identified broad genomic regions...
Paper Details
Title
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
Published Date
Jul 10, 2005
Journal
Volume
37
Issue
8
Pages
853 - 862
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Notes
History