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Intestinal barrier dysfunction in inflammatory bowel diseases.

Published on Jan 1, 2009in Inflammatory Bowel Diseases4.00
· DOI :10.1002/ibd.20539
Michael A. McGuckin49
Estimated H-index: 49
(UQ: University of Queensland),
Rajaraman Eri21
Estimated H-index: 21
(UQ: University of Queensland)
+ 2 AuthorsGraham L. Radford-Smith41
Estimated H-index: 41
(QIMR: QIMR Berghofer Medical Research Institute)
Cite
Abstract
The etiology of human inflammatory bowel diseases (IBDs) is believed to involve inappropriate host responses to the complex commensal microbial flora in the gut, although an altered commensal flora is not completely excluded. A multifunctional cellular and secreted barrier separates the microbial flora from host tissues. Altered function of this barrier remains a major largely unexplored pathway to IBD. Although there is evidence of barrier dysfunction in IBD, it remains unclear whether this is a primary contributor to disease or a consequence of mucosal inflammation. Recent evidence from animal models demonstrating that genetic defects restricted to the epithelium can initiate intestinal inflammation in the presence of normal underlying immunity has refocused attention on epithelial dysfunction in IBD. We review the components of the secreted and cellular barrier, their regulation, including interactions with underlying innate and adaptive immunity, evidence from animal models of the barrier's role in preventing intestinal inflammation, and evidence of barrier dysfunction in both Crohn's disease and ulcerative colitis. (Inflamm Bowel Dis 2008)
  • References (179)
  • Citations (325)
Cite
References179
Newest
Published on Jun 1, 2008in The Journal of Pathology5.94
Åsa V. Keita17
Estimated H-index: 17
(Linköping University),
Sa’ad Y. Salim6
Estimated H-index: 6
(Linköping University)
+ 5 AuthorsJohan D. Söderholm45
Estimated H-index: 45
(Linköping University)
Crohn's disease, a chronic inflammation of the bowel, is a multi-factorial condition where uncontrolled immune responses to luminal bacteria occur in genetically predisposed individuals. The first observable clinical signs are small ulcers that form at a specialised form of epithelium, follicle-associated epithelium (FAB). The FAB covers immune inductive sites, Peyer's patches, which function primarily as sensory areas that sample the externaI gut environment. Dendritic cells are one of the key ...
Published on Apr 15, 2008in Journal of Immunology4.72
Rana Al-Sadi16
Estimated H-index: 16
(UNM: University of New Mexico),
Dongmei Ye16
Estimated H-index: 16
(UNM: University of New Mexico)
+ 1 AuthorsThomas Y. Ma30
Estimated H-index: 30
(UNM: University of New Mexico)
The IL-1β-induced increase in intestinal epithelial tight junction (TJ) permeability has been postulated to be an important mechanism contributing to intestinal inflammation of Crohn’s disease and other inflammatory conditions of the gut. The intracellular and molecular mechanisms that mediate the IL-1β-induced increase in intestinal TJ permeability remain unclear. The purpose of this study was to elucidate the mechanisms that mediate the IL-1β-induced increase in intestinal TJ permeability. Spe...
Published on Mar 15, 2008in Journal of Immunology4.72
Junichi Nishimura22
Estimated H-index: 22
,
Hiroyuki Saiga11
Estimated H-index: 11
+ 10 AuthorsShizuo Akira234
Estimated H-index: 234
(Osaka University)
Secretory leukocyte protease inhibitor (SLPI) has multiple functions, including inhibition of protease activity, microbial growth, and inflammatory responses. In this study, we demonstrate that mouse SLPI is critically involved in innate host defense against pulmonary mycobacterial infection. During the early phase of respiratory infection with Mycobacterium bovis bacillus Calmette-Guerin, SLPI was produced by bronchial and alveolar epithelial cells, as well as alveolar macrophages, and secreted...
Published on Mar 4, 2008in PLOS Medicine
Chad K. Heazlewood1
Estimated H-index: 1
(UQ: University of Queensland),
Matthew C. Cook34
Estimated H-index: 34
+ 14 AuthorsMichael A. McGuckin49
Estimated H-index: 49
(UQ: University of Queensland)
Background MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. The inflammatory bowel disease ulcerative colitis is characterized by depleted goblet cells and a reduced mucus layer, but the aetiology remains obscure. In this study we used random mutagenesis to produce two murine models of inflammatory bowel disease, characterised the basis and nature of the inflammation in these mice, and compared the pathology with human ulcerative colitis.
Published on Mar 1, 2008in Biochimica et Biophysica Acta3.79
Akira Kanoh6
Estimated H-index: 6
(UTokyo: University of Tokyo),
Hideyuki Takeuchi25
Estimated H-index: 25
(UTokyo: University of Tokyo)
+ 3 AuthorsTatsuro Irimura47
Estimated H-index: 47
(UTokyo: University of Tokyo)
Abstract Mucus hypersecretion occurs as a consequence of the Th2 immune response in epithelia, yet it was not previously known whether the degree of O -glycosylation was modulated under such conditions. A colonic carcinoma cell line LS174T was used to assess the effect of interleukin (IL)-4 on the mRNA levels of eight pp-GalNAc-Ts. A three- to four-fold increase in pp-GalNAc-T1, T4, and T7 levels was observed. Lysates of untreated or IL-4-treated cells were examined for their ability to transfer...
Published on Feb 27, 2008in Gut17.94
Lisa A. Simms36
Estimated H-index: 36
,
James D. Doecke23
Estimated H-index: 23
+ 3 AuthorsGraham L. Radford-Smith41
Estimated H-index: 41
Background and aims: Reduced ileal Paneth cell alpha-defensin expression has been reported to be associated with Crohn9s disease (CD), especially in patients carrying NOD2 mutations. The aim of this study was to independently assess whether NOD2, alpha-defensins and CD are linked. Methods: Using quantitative RT-PCR, we measured the mRNA expression levels of key Paneth cell antimicrobial peptides (DEFA5, DEFA6, LYZ, PLA2G2A), inflammatory cytokines (IL6, IL8), and a marker of epithelial cell cont...
Published on Feb 1, 2008in The American Journal of Gastroenterology10.24
Rachel J. Adams3
Estimated H-index: 3
(UQ: University of Queensland),
Sharise P. Heazlewood1
Estimated H-index: 1
(UQ: University of Queensland)
+ 3 AuthorsTimothy H. Florin41
Estimated H-index: 41
(UQ: University of Queensland)
IgG Antibodies Against Common Gut Bacteria Are More Diagnostic for Crohn's Disease Than IgG Against Mannan or Flagellin
Published on Nov 15, 2007in Journal of Immunology4.72
Sean L. Barnes3
Estimated H-index: 3
(UVA: University of Virginia),
Alda Vidrich10
Estimated H-index: 10
(UVA: University of Virginia)
+ 5 AuthorsSteven M. Cohn25
Estimated H-index: 25
(UVA: University of Virginia)
SAMP1/Fc mice develop spontaneous ileitis that shares many features with human Crohn’s disease. One of the earliest features of ileitis in SAMP1/Fc mice is an increase in the number of ileal goblet and intermediate cells. Resistin-like molecule β (RELMβ) is a goblet cell-specific, cysteine-rich peptide previously shown to function as part of the innate immune response. In this study, we examined the role of expression of RELMβ in the initiation of ileal inflammation in SAMP1/Fc mice. RELMβ was h...
Published on Nov 1, 2007in Clinical Gastroenterology and Hepatology7.96
Salma Akram5
Estimated H-index: 5
(Mayo Clinic),
Joseph A. Murray64
Estimated H-index: 64
(Mayo Clinic)
+ 4 AuthorsSusan C. Abraham48
Estimated H-index: 48
(Mayo Clinic)
Background & Aims: Autoimmune enteropathy is a rare cause of intractable diarrhea associated with circulating gut autoantibodies and a predisposition to autoimmunity. It is rarely observed in adults, with only 11 cases reported to date. Methods: Fifteen adults with autoimmune enteropathy were identified at the Mayo Clinic, Rochester, from May 2001–June 2006. The demographic, clinical, and treatment data were abstracted from their records. Results: The study population was 87% white, 47% female, ...
Published on Oct 1, 2007in Gastroenterology19.23
Michael A. McGuckin49
Estimated H-index: 49
(UQ: University of Queensland),
Alison L. Every12
Estimated H-index: 12
(University of Melbourne)
+ 8 AuthorsRichard L. Ferrero33
Estimated H-index: 33
(Monash University, Clayton campus)
Background & Aims: The MUC1 mucin is expressed on the cell surface of epithelial cells lining the gastric mucosa. Epidemiologic studies suggest that functional allelic variations in the MUC1 gene may play a role in human susceptibility to Helicobacter pylori -associated pathologies, including gastric adenocarcinoma. We have evaluated the impact of Muc1 expression on the colonization and pathogenesis of gastric Helicobacter infections. Methods: Wild-type and Muc1-deficient mice were infected with...
Cited By325
Newest
Published on Feb 12, 2019in Scientific Reports4.01
Rasha H. Dosh (University of Kufa), Nicola Jordan-Mahy3
Estimated H-index: 3
(SHU: Sheffield Hallam University)
+ 1 AuthorsChristine L. Le Maitre23
Estimated H-index: 23
(SHU: Sheffield Hallam University)
The in vitro study of the pathogenesis of inflammatory bowel disease (IBD) requires a cell model which closely reflects the characteristics of the in vivo intestinal epithelium. This study aimed to investigate the application of L-pNIPAM hydrogel as a scaffold to develop a long-term 3D co-culture model of Caco-2 and HT29-MTX cells under conditions analogous to inflammation, to determine its potential use in studying IBD. Monocultures and co-cultures were layered on L-pNIPAM hydrogel scaffolds an...
Published on Feb 22, 2019in Journal of Translational Medicine4.10
Shin-Yi Tsai3
Estimated H-index: 3
(Mackay Medical College),
Hsuan-Ju Chen6
Estimated H-index: 6
(PRC: China Medical University (PRC))
+ 6 AuthorsChi Chen1
Estimated H-index: 1
(Mackay Memorial Hospital)
Background Similarities in the symptoms of chronic fatigue syndrome (CFS) and inflammatory bowel disease (IBD) have been observed as follows: severe disease activity in IBD correlates with severe fatigue, major psychiatric signs, the common use of medication, and bacterial translocation. One of several hypotheses for explaining the mechanisms underlying CFS suggests a similarity to the impaired intestinal mucosa of IBD. “This study investigated the risk of incident CFS among patients with IBD”.
Published on Nov 1, 2019in Fish & Shellfish Immunology3.30
Weihao Ou1
Estimated H-index: 1
(Ocean University of China),
Haibin Hu5
Estimated H-index: 5
(Ocean University of China)
+ 5 AuthorsKangsen Mai37
Estimated H-index: 37
(Ocean University of China)
Abstract A 12-week feeding trial was conducted to investigate the effect of dietary daidzein on the intestinal mucosal barrier function and the intestinal microbiota profile of juvenile turbot (Scophthalmus maximus L.). Three isonitrogenous and isolipidic experimental diets were formulated to contain 0 (FM), 40 (D.40) and 400 (D.400) mg kg−1 daidzein, respectively. Fish fed D.400 had significantly lower growth performance than fish fed D.40. Dietary daidzein significantly increased the feed effi...
Published on Sep 1, 2019in International Immunopharmacology3.36
Na Dong1
Estimated H-index: 1
(NEAU: Northeast Agricultural University),
Xinran Li1
Estimated H-index: 1
(NEAU: Northeast Agricultural University)
+ 5 AuthorsDeshan Li14
Estimated H-index: 14
(NEAU: Northeast Agricultural University)
Abstract Salmonella typhimurium ( S. t. ) is one of the main pathogens that causes acute gastroenteritis. To evaluate the anti-inflammatory mechanism of Astragalus polysaccharide (APS) in vivo and its influence on the intestinal flora, BALB/c mice were infected with S. t. to establish a model of diarrhea. The disease activity index (DAI) scores showed that APS attenuated S. t .-induced weight loss and diarrhea in mice. APS significantly reduced the index of the liver and spleen as well as the AL...
Jia Liu2
Estimated H-index: 2
,
Ling Yu + 4 AuthorsQing Wu7
Estimated H-index: 7
Inflammatory bowel disease (IBD) is a worldwide healthcare problem calling for the development of new therapeutic drugs. Angelica sinensis and Zingiber officinale Roscoe are two common dietetic Chinese herbs, which are traditionally used for complementary treatment of gastrointestinal disorders. As bioactive constituents, volatile and pungent substances of these two herbs could be effectively extracted together by supercritical fluid extraction. In this study, the supercritical fluid extract of ...
Doug N. Halligan2
Estimated H-index: 2
(UCD: University College Dublin),
Mohammed Naeem Khan2
Estimated H-index: 2
(Ulster University)
+ 5 AuthorsCormac T. Taylor50
Estimated H-index: 50
Inflammatory Bowel Disease (IBD) is characterized by epithelial barrier dysfunction with resultant inflammation as the mucosal immune system becomes exposed to luminal antigens. The hydroxylase inh...
Published on Jul 13, 2019in Cells
Stepan Coufal1
Estimated H-index: 1
,
Natalie Galanova + 9 AuthorsPavel Drastich11
Estimated H-index: 11
Crohn’s disease (CD), ulcerative colitis (UC) and inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC-IBD), share three major pathogenetic mechanisms of inflammatory bowel disease (IBD)-gut dysbiosis, gut barrier failure and immune system dysregulation. While clinical differences among them are well known, the underlying mechanisms are less explored. To gain an insight into the IBD pathogenesis and to find a specific biomarker pattern for each of them, we used pr...
Published on Oct 1, 2018in Journal of Ginseng Research4.03
Joonil Lee1
Estimated H-index: 1
(Kyung Hee University),
Kyoung Sun Park1
Estimated H-index: 1
(Kyung Hee University),
Ik-Hyun Cho21
Estimated H-index: 21
(Kyung Hee University)
Abstract Panax ginseng Meyer ( P. ginseng; Korean ginseng) is well known for its medicinal properties. It can alleviate pathological symptoms, promote health, and prevent potential diseases via its anti-inflammatory, antioxidant, homeostatic, and other positive effects on biological metabolism. Although many studies have determined effects of P. ginseng on various diseases, such as cardiovascular, neurological, and immunological diseases, little is known about the effect of P. ginseng on autoimm...
Published on Jul 1, 2019in Minerva Biotecnologica0.60
Gian Paolo Caviglia11
Estimated H-index: 11
,
Chiara Rosso14
Estimated H-index: 14
+ 4 AuthorsRinaldoPellicano23
Estimated H-index: 23
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