Pharmacokinetic‐pharmacodynamic crossover comparison of two levodopa extension strategies
Abstract
Controlled-release carbidopa and levodopa (CL-CR) and the combination of carbidopa, levodopa, and entacapone (CLE) are used for extending levodopa (L-dopa) effects. In a randomized, open-label crossover study of 17 PD subjects with wearing-off responses, we compared 8-hour L-dopa pharmacokinetics (PK) and clinical effects after two doses of CL-CR (50 and 200 mg, respectively) and CLE (37.7, 150, 200 mg, respectively). PK analysis revealed the...
Paper Details
Title
Pharmacokinetic‐pharmacodynamic crossover comparison of two levodopa extension strategies
Published Date
May 1, 2009
Journal
Volume
24
Issue
9
Pages
1319 - 1324
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