6-methoxytryptophol reduces lipopolysaccharide-induced lipid peroxidation in vitro more effectively than melatonin.

Bacterial lipopolysaccharide (LPS) causes lipid peroxidation (LPO). We have found that LPS induces LPO in tissue homogenates in vitro in a concentration-dependent manner, the concentration of 400 μg/ml demonstrating the most efficient lipid damaging effect. Antioxidant properties of melatonin are unquestionable and have been proved both in vivo and in vitro. It has been demonstrated that also melatonin metabolites and derivatives inhibit...