A quantitative analysis of kinase inhibitor selectivity
Abstract
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity are poorly defined, and an important step toward understanding the relationship between selectivity, efficacy and safety is the exploration of how inhibitors interact with the human kinome. We present interaction maps for 38 kinase inhibitors across a panel of 317 kinases representing >50% of the...
Paper Details
Title
A quantitative analysis of kinase inhibitor selectivity
Published Date
Jan 1, 2008
Journal
Volume
26
Issue
1
Pages
127 - 132
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