Impairment of paravascular clearance pathways in the aging brain
Abstract
In the brain, protein waste removal is partly performed by paravascular pathways that facilitate convective exchange of water and soluble contents between cerebrospinal fluid (CSF) and interstitial fluid (ISF). Several lines of evidence suggest that bulk flow drainage via the glymphatic system is driven by cerebrovascular pulsation, and is dependent on astroglial water channels that line paravascular CSF pathways. The objective of this study was...
Paper Details
Title
Impairment of paravascular clearance pathways in the aging brain
Published Date
Sep 26, 2014
Journal
Volume
76
Issue
6
Pages
845 - 861
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History