Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
Abstract
Recent advances in high-throughput cDNA sequencing (RNA-seq) can reveal new genes and splice variants and quantify expression genome-wide in a single assay. The volume and complexity of data from RNA-seq experiments necessitate scalable, fast and mathematically principled analysis software. TopHat and Cufflinks are free, open-source software tools for gene discovery and comprehensive expression analysis of high-throughput mRNA sequencing...
Paper Details
Title
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
Published Date
Mar 1, 2012
Journal
Volume
7
Issue
3
Pages
562 - 578
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