Dietary strategies to treat hyperhomocysteinaemia based on the biochemistry of homocysteine: a review

Hyperhomocysteinaemia is implicated in various diseases, including cardiovascular disease and cancer. Several conditions influence the concentration of homocysteine (Hcy), including demographic, genetic and lifestyle factors. With regard to the latter, dietary components may be manipulated as Hcy can be remethylated to methionine by folate, or metabolised by other one‑carbon nutrients, such as betaine and its precursor, choline. This metabolic...