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Sleep, sleep-disordered breathing and metabolic consequences

Published on Jul 1, 2009in European Respiratory Journal11.81
· DOI :10.1183/09031936.00166808
Patrick Levy53
Estimated H-index: 53
,
Marisa Bonsignore36
Estimated H-index: 36
,
J. Eckel3
Estimated H-index: 3
Cite
Abstract
Sleep profoundly affects metabolic pathways. In healthy subjects, experimental sleep restriction caused insulin resistance (IR) and increased evening cortisol and sympathetic activation. Increased obesity in subjects reporting short sleep duration leads to speculation that, during recent decades, decreased sleeping time in the general population may have contributed to the increasing prevalence of obesity. Causal inference is difficult due to lack of control for confounders and inconsistent evidence of temporal sequence. In the general population, obstructive sleep apnoea (OSA) is associated with glucose intolerance. OSA severity is also associated with the degree of IR. However, OSA at baseline does not seem to significantly predict the development of diabetes. Prevalence of the metabolic syndrome is higher in patients with OSA than in obese subjects without OSA. Treatment with continuous positive airway pressure seems to improve glucose metabolism both in diabetic and nondiabetic OSA but mainly in nonobese subjects. The relative role of obesity and OSA in the pathogenesis of metabolic alterations is still unclear and is intensively studied in clinical and experimental models. In the intermittent hypoxia model in rodents, strong interactions are likely to occur between haemodynamic alterations, systemic inflammation and metabolic changes, modulated by genetic background. Molecular and cellular mechanisms are currently being investigated.
  • References (194)
  • Citations (225)
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References194
Newest
Published on May 1, 2009in Sleep and Breathing2.33
Stijn Verhulst24
Estimated H-index: 24
(University of Antwerp),
Sarah Jacobs3
Estimated H-index: 3
(University of Antwerp)
+ 6 AuthorsKristine Desager28
Estimated H-index: 28
(University of Antwerp)
Introduction The aim of this retrospective study was to investigate if sleep-disordered breathing (SDB) was an independent predictor of suspected fatty liver disease in a clinical sample of overweight children and adolescents.
Published on May 1, 2009in European Respiratory Journal11.81
John F. Garvey10
Estimated H-index: 10
,
Cormac T. Taylor50
Estimated H-index: 50
,
Walter T. McNicholas49
Estimated H-index: 49
(UCD: University College Dublin)
There is increasing evidence that intermittent hypoxia plays a role in the development of cardiovascular risk in obstructive sleep apnoea syndrome (OSAS) through the activation of inflammatory pathways. The development of translational models of intermittent hypoxia has allowed investigation of its role in the activation of inflammatory mechanisms and promotion of cardiovascular disease in OSAS. There are noticeable differences in the response to intermittent hypoxia between body tissues but the...
Published on Jan 1, 2009in International Journal of Obesity4.51
Stijn Verhulst24
Estimated H-index: 24
,
R. Rooman14
Estimated H-index: 14
+ 2 AuthorsKristine Desager28
Estimated H-index: 28
Sleep-disordered breathing is highly prevalent in childhood obesity. Two recent cross-sectional studies have demonstrated an independent association between the severity of sleep-disordered breathing and the metabolic syndrome. A limited number of studies have also addressed the correlation between sleep-disordered breathing and insulin resistance, the core factor of the metabolic syndrome. Cross-sectional reports in modestly obese children are in favor of an association between sleep apnea and ...
Arthur Dawson9
Estimated H-index: 9
,
Susan L. Abel2
Estimated H-index: 2
+ 5 AuthorsLawrence E. Kline11
Estimated H-index: 11
Obstructive sleep apnea (OSA) and type 2 diabetes mellitus are frequently comorbid conditions. Clinic-based estimates of the prevalence of OSA in type 2 diabetics range from 18% to as high as 36%,1–3 and some 50% of patients with OSA have type 2 diabetes or impaired carbohydrate metabolism.4 Population surveys, the Wisconsin Sleep Cohort,5 and the Sleep Heart Health Study6 estimate the prevalence of type 2 diabetes in patients with OSA (apnea-hypopnea index [AHI] > 15) to be about 15%. Obesity i...
Published on Nov 7, 2008in Circulation Research15.86
Vladimir Savransky15
Estimated H-index: 15
(Johns Hopkins University),
Jonathan C. Jun23
Estimated H-index: 23
+ 9 AuthorsSanjay Bhanot1
Estimated H-index: 1
(Johns Hopkins University)
Obstructive sleep apnea leads to chronic intermittent hypoxia (CIH) and is associated with atherosclerosis. We have previously shown that C57BL/6J mice exposed to CIH and a high-cholesterol diet develop dyslipidemia, atherosclerosis of the aorta, and upregulation of a hepatic enzyme of lipoprotein secretion, stearoyl coenzyme A desaturase 1 (SCD-1). We hypothesized that (1) SCD-1 deficiency will prevent dyslipidemia and atherosclerosis during CIH; and (2) human OSA is associated with dyslipidemi...
Published on Nov 1, 2008in Thorax9.64
Antonia Barceló23
Estimated H-index: 23
,
Ferrán Barbé Illa44
Estimated H-index: 44
+ 4 AuthorsAlvar Agusti88
Estimated H-index: 88
Background: Excessive daytime sleepiness (EDS), obesity and insulin resistance (IR) occur frequently in patients with obstructive sleep apnoea syndrome (OSAS). We hypothesised that in these patients, EDS is a marker of IR, independent of obesity. Methods: We studied 44 patients with OSAS (22 with and 22 without EDS) matched for age (±5 years), body mass index (BMI ±3 kg/m 2 ) and severity of OSAS (as determined by the apnoea–hypopnoea index (AHI)), and 23 healthy controls. Patients (n = 35) were...
Published on Oct 3, 2008in Thorax9.64
Malcolm Kohler26
Estimated H-index: 26
,
Lisa Ayers12
Estimated H-index: 12
+ 7 AuthorsJohn Stradling63
Estimated H-index: 63
Background: Obstructive sleep apnoea syndrome (OSAS) has been associated with cardiovascular disease in epidemiological and observational studies. Continuous positive airway pressure (CPAP) is the treatment of choice for OSAS, but the impact of this intervention on systemic inflammation involved in the atherosclerotic process remains unclear. Methods: 100 men with moderate–severe OSAS were randomised to therapeutic (n = 51) or subtherapeutic (n = 49) CPAP treatment for 4 weeks to investigate the...
Published on Oct 1, 2008in Sleep Medicine Reviews10.52
Stijn Verhulst24
Estimated H-index: 24
(University of Antwerp),
L. Van Gaal64
Estimated H-index: 64
(University of Antwerp)
+ 1 AuthorsKristine Desager28
Estimated H-index: 28
(University of Antwerp)
Summary The prevalence of childhood obesity is increasing worldwide. One of the obesity-related complications that has received increasing attention in recent years is sleep-disordered breathing. Obese children are at a higher risk of developing sleep-disordered breathing, including habitual snoring, obstructive sleep apnea syndrome and desaturations preceded by central apneas. Both adiposity and upper airway factors, such as adenotonsillar hypertrophy, modulate the severity of sleep-disordered ...
Published on Oct 1, 2008in Sleep Medicine Reviews10.52
Mark Kohler15
Estimated H-index: 15
(University of Adelaide),
Cameron J. van den Heuvel24
Estimated H-index: 24
(University of Adelaide)
Summary The proportion of children who are overweight or obese has risen steadily in recent decades and approaches a quarter of all children in Western countries. This global epidemic of excess weight and adiposity in humans is associated with increased morbidity and mortality, especially related to diabetes and poor cardiovascular health. It would appear that obesity is also generally accepted to be an important risk factor in the development of sleep disordered breathing (SDB), in children as ...
Published on Oct 1, 2008in Chest9.66
Zuzana Dorkova7
Estimated H-index: 7
,
Darina Petrasova7
Estimated H-index: 7
+ 2 AuthorsRuzena Tkacova21
Estimated H-index: 21
Background The increased risk of atherosclerotic morbidity and mortality in patients with obstructive sleep apnea (OSA) has been linked to arterial hypertension, insulin resistance, systemic inflammation, and oxidative stress. We aimed to determine the effects of 8 weeks of therapy with continuous positive airway pressure (CPAP) on glucose and lipid profile, systemic inflammation, oxidative stress, and global cardiovascular disease (CVD) risk in patients with severe OSA and metabolic syndrome. M...
Cited By225
Newest
Published on Jan 1, 2020in Internal Medicine0.96
Yuki Isobe2
Estimated H-index: 2
(Kanazawa University),
Yasuto Nakatsumi8
Estimated H-index: 8
(Kanazawa University)
+ 6 AuthorsToshinari Takamura40
Estimated H-index: 40
(Kanazawa University)
Published on 2019in Journal of Cellular Physiology4.52
Tianyun Yang (XinHua Hospital), Jinyuan Sun (XinHua Hospital)+ 1 AuthorsSong Liu1
Estimated H-index: 1
(XinHua Hospital)
Published on Sep 15, 2019in Oxidative Medicine and Cellular Longevity4.87
Qingshi Chen (Fujian Medical University), Guofu Lin (Fujian Medical University)+ 5 AuthorsQi-Chang Lin8
Estimated H-index: 8
(Fujian Medical University)
Purpose. The efficacy of obstructive sleep apnea (OSA) therapy with continuous positive airway pressure (CPAP) on uric acid (UA) yielded conflicting results. This meta-analysis was performed to assess whether OSA treatment with CPAP could reduce UA levels. Methods. The Web of Science, Cochrane Library, Embase, and PubMed were searched before March 2019. Information of patients, study design, and pre- and post-CPAP treatment of UA was utilized for analysis. The overall effects were analyzed via t...
Published on Aug 26, 2019in Journal of International Medical Research1.35
ObjectiveBoth obstructive sleep apnea–hypopnea syndrome (OSAHS) and type 2 diabetes mellitus (T2DM) are closely related to the renin-angiotensin-aldosterone system. We investigated whether hyperald...
Published on Jun 1, 2019in Sleep and Breathing2.33
Zeng-Hong Wu (HUST: Huazhong University of Science and Technology), Xiuping Yang (HUST: Huazhong University of Science and Technology)+ 2 AuthorsXiong Chen7
Estimated H-index: 7
(HUST: Huazhong University of Science and Technology)
Background Obstructive sleep apnea hypopnea syndrome (OSAHS) means apnea and hypopnea caused by partial or complete obstruction of upper airway collapse during sleep. Gastroesophageal reflux disease (GERD) is believed to be associated with various manifestations in the otorhinolaryngology and has been found to be an additional risk factor for OSAHS.
Published on Apr 7, 2019in European Heart Journal23.24
Ali Azarbarzin11
Estimated H-index: 11
(Brigham and Women's Hospital),
Scott A. Sands31
Estimated H-index: 31
(Brigham and Women's Hospital)
+ 9 AuthorsDavid P. White82
Estimated H-index: 82
(Brigham and Women's Hospital)
Apnoea-hypopnoea index (AHI), the universal clinical metric of sleep apnoea severity, poorly predicts the adverse outcomes of sleep apnoea, potentially because the AHI, a frequency measure, does not adequately capture disease burden. Therefore, we sought to evaluate whether quantifying the severity of sleep apnoea by the 'hypoxic burden' would predict mortality among adults aged 40 and older. The samples were derived from two cohort studies: The Outcomes of Sleep Disorders in Older Men (MrOS), w...
Published on Mar 1, 2019in Sleep and Breathing2.33
Benedikt Hofauer11
Estimated H-index: 11
(TUM: Technische Universität München),
Armin Steffen12
Estimated H-index: 12
+ 2 AuthorsClemens Heiser13
Estimated H-index: 13
(TUM: Technische Universität München)
Objective Selective upper airway stimulation (sUAS) is a new treatment modality for patients with obstructive sleep apnea (OSA) and continuous positive airway pressure (CPAP) failure. The aim of this study was to analyze therapy adherence and to structure patient experience reports.
Published on Mar 1, 2019in Sleep and Breathing2.33
Haibo Ding5
Estimated H-index: 5
(Fujian Medical University),
Jie-Feng Huang3
Estimated H-index: 3
(Fujian Medical University)
+ 4 AuthorsQi-Chang Lin8
Estimated H-index: 8
(Fujian Medical University)
Purpose Growing evidence has revealed that nonalcoholic fatty liver disease (NAFLD) is associated with type 2 diabetes. This study aimed to assess the association between glycometabolism and NAFLD in patients with obstructive sleep apnea (OSA).
Published on Feb 12, 2019in Frontiers in Nutrition
Paul Trayhurn57
Estimated H-index: 57
(UCB: University of Buckingham)
Gaseous oxygen is essential for all aerobic animals, without which mitochondrial respiration and oxidative phosphorylation cannot take place. It is not, however, regarded as a ‘nutrient’ by nutritionists and does not feature as such within the discipline of nutritional science. This is primarily a consequence of the route by which O2 enters the body, which is via the nose and lungs in terrestrial animals as opposed to the mouth and gastrointestinal tract for what are customarily considered as nu...
Published on Dec 1, 2018in Sleep and Breathing2.33
Xin Liu1
Estimated H-index: 1
(Tianjin Medical University General Hospital),
Yuyang Miao5
Estimated H-index: 5
(Tianjin Medical University)
+ 2 AuthorsQiang Zhang8
Estimated H-index: 8
(Tianjin Medical University General Hospital)
Obstructive sleep apnea (OSA) may play an important role in the progression of nonalcoholic fatty liver disease (NAFLD).The effect of continuous positive airway pressure (CPAP) treatment, the first-line therapy for OSA, on liver disease in OSA patients is still debated. We provide this review of previous studies to summarize the effects of CPAP treatment on liver disease in OSA patients in aspects of liver function, liver steatosis, fibrosis, and incidence of liver disease. CPAP treatment may be...
View next paperLong-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study.