Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch.
Loading Scinapse...
Strength, But Not Muscle Mass, Is Associated With Mortality in the Health, Aging and Body Composition Study Cohort
Published on Jan 1, 2006in Journals of Gerontology Series A-biological Sciences and Medical Sciences 4.90
· DOI :10.1093/gerona/61.1.72
Anne B. Newman134
Estimated H-index: 134
(University of Pittsburgh),
Varant Kupelian3
Estimated H-index: 3
+ 6 AuthorsTamara B. Harris112
Estimated H-index: 112
(National Institutes of Health)
Background. Although muscle strength and mass are highly correlated, the relationship between direct measures of low muscle mass (sarcopenia) and strength in association with mortality has not been examined. Methods. Total mortality rates were examined in the Health, Aging and Body Composition (Health ABC) Study in 2292 participants (aged 70–79 years, 51.6% women, and 38.8% black). Knee extension strength was measured with isokinetic dynamometry, grip strength with isometric dynamometry. Thigh muscle area was measured by computed tomography (CT) scan, and leg and arm lean soft tissue mass were determined by dual energy x-ray absorptiometry (DXA). Both strength and muscle size were assessed as in gender-specific Cox proportional hazards models, with age, race, comorbidities, smoking status, level of physical activity, fat area by CT or fat mass by DXA, height, and markers of inflammation, including interleukin-6, C-reactive protein, and tumor necrosis factor-a considered as potential confounders. Results. There were 286 deaths over an average of 4.9 (standard deviation ¼ 0.9) years of follow-up. Both quadriceps and grip strength were strongly related to mortality. For quadriceps strength (per standard deviation of 38 Nm), the crude hazard ratio for men was 1.51 (95% confidence interval, 1.28–1.79) and 1.65 (95% confidence interval, 1.19–2.30) for women. Muscle size, determined by either CT area or DXA regional lean mass, was not strongly related to mortality. In the models of quadriceps strength and mortality, adjustment for muscle area or regional lean mass only slightly attenuated the associations. Further adjustment for other factors also had minimal effect on the association of quadriceps strength with mortality. Associations of grip strength with mortality were similar. Conclusion. Low muscle mass did not explain the strong association of strength with mortality, demonstrating that muscle strength as a marker of muscle quality is more important than quantity in estimating mortality risk. Grip strength provided risk estimates similar to those of quadriceps strength.
  • Full text
  • References (29)
  • Cited By (763)
Published on Apr 1, 2004in Journal of the American Geriatrics Society 4.16
Jennifer S. Brach43
Estimated H-index: 43
(University of California, San Francisco),
Eleanor Marie Simonsick88
Estimated H-index: 88
(University of California, San Francisco)
+ 2 AuthorsAnne B. Newman27
Estimated H-index: 27
(University of California, San Francisco)
OBJECTIVES: To determine whether older adults who exercise demonstrate higher levels of physical function than those who do not exercise but are physically active throughout the day. DESIGN: Cross-sectional examination of baseline data from the Health, Aging and Body Composition (Health ABC) study. SETTING: Health ABC field centers in Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Three thousand seventy-five well-functioning black and white men and women aged 70 to 79. MEASUREME...
309 Citations Source Cite
Published on May 1, 2002in Medicine and Science in Sports and Exercise 4.29
Peter T. Katzmarzyk80
Estimated H-index: 80
Cora L. Craig39
Estimated H-index: 39
Purpose: To quantify the relationship between musculoskeletal fitness and all-cause mortality in the Canadian population. Methods: The sample consisted of 8116 people (3933 men and 4183 women), aged 20-69 yr, who participated in the 1981 Canada Fitness Survey. Measures of musculoskeletal fitness included sit-ups, push-ups, grip strength, and sit-and-reach trunk flexibility. In the 13 yr after the Canada Fitness Survey, there were 238 deaths and a total of 101,685 person-years. Proportional hazar...
122 Citations Source Cite
Published on Feb 1, 1997in Journal of the American Geriatrics Society 4.16
Tamara B. Harris112
Estimated H-index: 112
(National Institutes of Health),
Douglas P. Kiel95
Estimated H-index: 95
(Harvard University)
+ 4 AuthorsPeter W.F. Wilson149
Estimated H-index: 149
OBJECTIVES: We examined correlates of insulin-like growth factor-I (IGF-I), an indicator of growth hormone levels, to identify factors associated with higher levels of IGF-I in old age. DESIGN: Nested study of cross-sectional correlates and early-life predictors of IGF-I level. SETTING: A longitudinal cohort study, the Framingham Heart Study. PARTICIPANTS: A total of 790 men and women (mean age 78.5, range 72–94), who had weight, waist and hip circumferences measured at the time of IGF-I measure...
78 Citations Source Cite
Published on Jan 25, 2006in Annals of the New York Academy of Sciences 4.28
R. N. Baumgartner1
Estimated H-index: 1
(University of New Mexico)
Abstract: Health risks in elderly people cannot be evaluated simply in conventional terms of body fatness or fat distribution. Elderly people have less muscle and bone mass, expanded extracellular fluid volumes, and reduced body cell mass compared to younger adults. These nonfat components of body composition play critical roles, influencing cognitive and physical functional status, nutritional and endocrine status, quality of life, and comorbidity in elderly people. Different patterns of “disor...
547 Citations Source Cite
Published on Jul 1, 2002in Journal of the American Geriatrics Society 4.16
Soham Al Snih16
Estimated H-index: 16
(University of Texas Medical Branch),
Kyriakos S. Markides62
Estimated H-index: 62
(University of Texas Medical Branch)
+ 2 AuthorsJames S. Goodwin81
Estimated H-index: 81
(University of Texas Medical Branch)
OBJECTIVES: To examine the association between handgrip strength and mortality in older Mexican American men and women. DESIGN: A 5-year prospective cohort study. SETTING: Five southwestern states: Texas, New Mexico, Colorado, Arizona, and California. PARTICIPANTS: A population-based sample of 2,488 noninstitutionalized Mexican-American men and women aged 65 and older. MEASUREMENTS: Maximal handgrip strength, timed walk, and body mass index were assessed at baseline during 1993/94. Self-reports ...
177 Citations Source Cite
Published on Feb 10, 1999in JAMA 47.66
Taina Rantanen48
Estimated H-index: 48
Jack M. Guralnik69
Estimated H-index: 69
+ 4 AuthorsLon R. White76
Estimated H-index: 76
ContextPoor muscle strength, functional limitations, and disability often coexist, but whether muscle strength during midlife predicts old age functional ability is not known.ObjectiveTo determine whether hand grip strength measured during midlife predicts old age functional limitations and disability in initially healthy men.Design and SettingA 25-year prospective cohort study, the Honolulu Heart Program, which began in 1965 among Japanese-American men living on Oahu, Hawaii.ParticipantsA total...
899 Citations Source Cite
Published on May 1, 2003in Journal of the American Geriatrics Society 4.16
Taina Rantanen12
Estimated H-index: 12
(University of Jyväskylä),
Stefano Volpato52
Estimated H-index: 52
(National Institutes of Health)
+ 3 AuthorsJack M. Guralnik121
Estimated H-index: 121
(National Institutes of Health)
OBJECTIVES: To examine the association between muscle strength and total and cause-specific mortality and the plausible contributing factors to this association, such as presence of diseases commonly underlying mortality, inflammation, nutritional deficiency, physical inactivity, smoking, and depression. DESIGN: Prospective population-based cohort study with mortality surveillance over 5 years. SETTING: Elderly women residing in the eastern half of Baltimore, Maryland, and part of Baltimore Coun...
404 Citations Source Cite
Published on Dec 1, 2002in Journal of the American Geriatrics Society 4.16
Luigi Ferrucci138
Estimated H-index: 138
(National Institutes of Health),
Brenda W. J. H. Penninx47
Estimated H-index: 47
(Wake Forest University)
+ 6 AuthorsJack M. Guralnik121
Estimated H-index: 121
(National Institutes of Health)
OBJECTIVES: To test whether accelerated sarcopenia in older persons with high interleukin (IL)-6 serum levels plays a role in the prospective association between inflammation and disability found in many studies. DESIGN: Cohort study of older women with moderate to severe disability. PARTICIPANTS: Six hundred twenty older women from the Women's Health and Aging Study in whom information on baseline IL-6 serum level was available. MEASUREMENTS: Self-report of functional status, objective measures...
401 Citations Source Cite
Published on Mar 1, 2004in Journal of Vascular Surgery 3.29
Mary McGrae McDermott72
Estimated H-index: 72
(Northwestern University),
Michael H. Criqui108
Estimated H-index: 108
(University of California, San Diego)
+ 9 AuthorsCharles Woolley8
Estimated H-index: 8
(University of Michigan)
Abstract Objective The purpose of this study was to determine relationships between lower-extremity arterial obstruction, leg strength, and lower-extremity functioning. Design The study design was cross-sectional. A total of 514 outpatients (269 with ankle-brachial index [ABI] Main outcome measures Strength in each leg, 6-minute walk, 4-meter walking velocity, accelerometer-measured physical activity, and a summary performance score were measured. The summary performance score is a composite mea...
88 Citations Source Cite
Published on Mar 1, 2003in Journal of the American Geriatrics Society 4.16
Anne B. Newman134
Estimated H-index: 134
(University of Pittsburgh),
Catherine L. Haggerty28
Estimated H-index: 28
(University of Pittsburgh)
+ 5 AuthorsMarjolein Visser75
Estimated H-index: 75
(VU University Amsterdam)
OBJECTIVES: To determine whether lower lean mass and higher fat mass have independent effects on the loss of strength and muscle quality in older adults and might explain part of the effect of age. DESIGN: Single-episode, cross-sectional analyses of a cohort of subjects in the Health, Aging and Body Composition (Health ABC) Study. SETTING: Ambulatory clinic and research laboratory. PARTICIPANTS: Two thousand six hundred twenty-three men and women aged 70 to 79 from the Health ABC Study. MEASUREM...
297 Citations Source Cite
Cited By763
Published on Jan 1, 2014
Peter Francis4
Estimated H-index: 4
Published on Jan 1, 2013
Eugene J. Pietzak5
Estimated H-index: 5
(Hospital of the University of Pennsylvania),
Thomas J. Guzzo27
Estimated H-index: 27
(Hospital of the University of Pennsylvania)
The elderly population is the fastest growing age group in the United States. This will likely result in more elderly patients presenting for urologic surgery annually. When considering a patient for surgery, age alone should not be a contraindication. The decision on surgery should be individualized for the patient and their problem.
Source Cite
Published on Jan 1, 2014in Advances in food and nutrition research
Alessandro Laviano40
Estimated H-index: 40
(Sapienza University of Rome),
Chiara Serena Gori4
Estimated H-index: 4
(Sapienza University of Rome),
Serena Rianda4
Estimated H-index: 4
(Sapienza University of Rome)
Abstract Preserving or restoring adequate nutritional status is a key factor to delay the onset of chronic diseases and to accelerate recovery from acute illnesses. In particular, consistent and robust data show the loss of muscle mass, that is, sarcopenia, is clinically relevant since it is closely related to increased morbidity and mortality in healthy individuals and patients. Sarcopenia is defined as the age-related loss of muscle mass and function. International study groups have recently p...
14 Citations Source Cite
Published on Jan 1, 2013
Study 1 Purpose. The purpose of this study was to determine whether awareness and utilization of fitness resources and overall physical activity engagement differed depending on residential distance from community-based fitness resources (CBFR). Methods. Four hundred and seventeen older adults (72.9 ± 7.7 years) were randomly recruited from three spatial tiers (≤1, >1 to ≤2, and >2 to 5 miles) surrounding seven senior centers, which housed CBFR. Participants were mailed and returned a health his...
Published on Nov 9, 2011
The sphingolipids are a family of membrane lipids with only a structural role, influencing lipid bilayer properties, but they also act as effector molecules with essential roles in many aspects of cell biology. The sphingolipids ceramide, sphingosine and S1P have shown opposite effects: whereas ceramide and sphingosine usually inhibit proliferation and promote apoptotic responses to different stress stimuli, S1P is known to stimulate cell growth, and promote cell survival. Ceramide can be produc...
Published on Dec 13, 2012
La diminution de la force et l'exacerbation de la fatigue neuromusculaire sont fortement impliquees dans l'alteration des capacites fonctionnelles, de la tolerance a l'effort et du pronostic de patients porteurs de pathologies chroniques variees. Ces alterations peuvent trouver leurs origines dans des atteintes primaires de la fonction neuromusculaire et/ou des atteintes secondaires causees par exemple, par une diminution de l'activite spontanee favorisee par une pathologie chronique. Ainsi, la ...
Published on Jul 1, 2011in Medicine and Science in Sports and Exercise 4.29
Carol Ewing Garber18
Estimated H-index: 18
Bryan Blissmer21
Estimated H-index: 21
+ 5 AuthorsDavid P. Swain25
Estimated H-index: 25
The purpose of this Position Stand is to provide guidance to professionals who counsel and prescribe individualized exercise to apparently healthy adults of all ages. These recommendations also may apply to adults with certain chronic diseases or disabilities, when appropriately evaluated and advised by a health professional. This document supersedes the 1998 American College of Sports Medicine (ACSM) Position Stand, "The Recommended Quantity and Quality of Exercise for Developing and Maintainin...
2,797 Citations Source Cite
Published on Jan 1, 2014
Joanne C Trezise1
Estimated H-index: 1
(Edith Cowan University)
v List of Tables xi List of Figures xiii List of Abbreviations xiv CHAPTER ONE: INTRODUCTION 1 2.
1 Citations
Published on Jan 1, 2014
Maria Fernandez-del-Valle2
Estimated H-index: 2
(Texas Tech University),
Tyrel S. McCravens (Texas Tech University)
Due to recent changes in physical activity practices, strength training, or resistance training, has become an area of focus in the research of determining the overall health of an individual. As individuals age, disorders relating to both bone and muscle begin to cause a decline in health and functional activity. Bone disorders, such as osteoporosis and osteopenia, have been linked to muscle disorders like sarcopenia (a loss of skeletal muscle mass). While these disorders do affect males, femal...
Source Cite
View next paperThe healthcare costs of sarcopenia in the United States