Weight loss after gastric bypass surgery in human obesity remodels promoter methylation.
Abstract
DNA methylation provides a mechanism by which environmental factors can control insulin sensitivity in obesity. Here, we assessed DNA methylation in skeletal muscle from obese people before and after Roux-en-Y gastric bypass (RYGB). Obesity was associated with altered expression of a subset of genes enriched in metabolic process and mitochondrial function. After weight loss, the expression of the majority of the identified genes was normalized...
Paper Details
Title
Weight loss after gastric bypass surgery in human obesity remodels promoter methylation.
Published Date
Apr 25, 2013
Journal
Volume
3
Issue
4
Pages
1020 - 1027
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Notes
History