Match!

Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome

Published on Nov 1, 2010in American Journal of Physiology-endocrinology and Metabolism4.13
· DOI :10.1152/ajpendo.00283.2010
Mark J. Dekker5
Estimated H-index: 5
(U of T: University of Toronto),
Qiaozhu Su11
Estimated H-index: 11
+ 2 AuthorsKhosrow Adeli55
Estimated H-index: 55
(U of T: University of Toronto)
Abstract
As dietary exposure to fructose has increased over the past 40 years, there is growing concern that high fructose consumption in humans may be in part responsible for the rising incidence of obesity worldwide. Obesity is associated with a host of metabolic challenges, collectively termed the metabolic syndrome. Fructose is a highly lipogenic sugar that has profound metabolic effects in the liver and has been associated with many of the components of the metabolic syndrome (insulin resistance, elevated waist circumference, dyslipidemia, and hypertension). Recent evidence has also uncovered effects of fructose in other tissues, including adipose tissue, the brain, and the gastrointestinal system, that may provide new insight into the metabolic consequences of high-fructose diets. Fructose feeding has now been shown to alter gene expression patterns (such as peroxisome proliferator-activated receptor-γ coactivator-1α/β in the liver), alter satiety factors in the brain, increase inflammation, reactive oxygen species, and portal endotoxin concentrations via Toll-like receptors, and induce leptin resistance. This review highlights recent findings in fructose feeding studies in both human and animal models with a focus on the molecular and biochemical mechanisms that underlie the development of insulin resistance, hepatic steatosis, and the metabolic syndrome.
  • References (148)
  • Citations (254)
References148
Newest
#1Jian-Mei Li (NU: Nanjing University)H-Index: 10
#2Y. Li (NU: Nanjing University)H-Index: 14
Last.Qing-Hua Hu (NU: Nanjing University)H-Index: 12
view all 4 authors...
73 CitationsSource
#1Joanne Hsieh (U of T: University of Toronto)H-Index: 7
#2Christine Longuet (U of T: University of Toronto)H-Index: 7
Last.Khosrow Adeli (U of T: University of Toronto)H-Index: 55
view all 7 authors...
170 CitationsSource
#1Synia Haub (University of Hohenheim)H-Index: 5
#2Giridhar Kanuri (University of Hohenheim)H-Index: 14
Last.Ina Bergheim (University of Hohenheim)H-Index: 32
view all 6 authors...
47 CitationsSource
#1Luc Tappy (UNIL: University of Lausanne)H-Index: 55
#2Kim-Anne Lê (UNIL: University of Lausanne)H-Index: 18
698 CitationsSource
496 CitationsSource
#1Joo Y. Lee (UC Davis: University of California, Davis)H-Index: 22
#2Ling Zhao (UC Davis: University of California, Davis)H-Index: 16
Last.Daniel H. Hwang (Gwangju Institute of Science and Technology)H-Index: 48
view all 3 authors...
99 CitationsSource
#1Hyun Young Koo (UIUC: University of Illinois at Urbana–Champaign)H-Index: 4
#2Michio Miyashita (Nihon University)H-Index: 1
Last.Manabu T. Nakamura (UIUC: University of Illinois at Urbana–Champaign)H-Index: 31
view all 4 authors...
59 CitationsSource
#1Patrice D. Cani (UCL: Université catholique de Louvain)H-Index: 80
#2Nathalie M. Delzenne (UCL: Université catholique de Louvain)H-Index: 79
249 CitationsSource
#1Yassine Sakar (French Institute of Health and Medical Research)H-Index: 6
#2Corinne Nazaret (French Institute of Health and Medical Research)H-Index: 11
Last.André Bado (French Institute of Health and Medical Research)H-Index: 31
view all 8 authors...
50 CitationsSource
#1Astrid Spruss (University of Hohenheim)H-Index: 18
#2Giridhar Kanuri (University of Hohenheim)H-Index: 14
Last.Ina Bergheim (University of Hohenheim)H-Index: 32
view all 6 authors...
344 CitationsSource
Cited By254
Newest
#1S. S. Loza-Medrano (IPN: Instituto Politécnico Nacional)
#2Luis Arturo Baiza-Gutman (UNAM: National Autonomous University of Mexico)H-Index: 9
Last.Margarita Díaz-Flores (Mexican Social Security Institute)H-Index: 14
view all 10 authors...
Source
#1Chisato NagataH-Index: 48
#2Keiko WadaH-Index: 16
Last.Takahiro UjiH-Index: 1
view all 8 authors...
Source
#1María Luisa OjedaH-Index: 7
#2Fátima NogalesH-Index: 12
Last.Olimpia CarrerasH-Index: 13
view all 5 authors...
Source
Source
Source
#1Nataša Veličković (University of Belgrade)H-Index: 10
#2Ana Teofilović (University of Belgrade)H-Index: 2
Last.Gordana Matić (University of Belgrade)H-Index: 16
view all 9 authors...
3 CitationsSource
#1Daniela GabbiaH-Index: 5
#2Marco RoversoH-Index: 6
Last.Sara De MartinH-Index: 12
view all 11 authors...
1 CitationsSource
#1Rutiane Ullmann Thoen (UHSA: University of Health Sciences Antigua)
#2Nathaniele Nebel Barther (UHSA: University of Health Sciences Antigua)
Last.Marilene Porawski (UHSA: University of Health Sciences Antigua)
view all 10 authors...
Source
#1Senay Topsakal (Pamukkale University)H-Index: 6
#2Ozlem Ozmen (Mehmet Akif Ersoy University)H-Index: 11
Last.M. Ozgocmen (Süleyman Demirel University)
view all 3 authors...
Source
#1Steve LeuH-Index: 25
#2Kay L.H. WuH-Index: 9
Last.Julie ChanH-Index: 15
view all 5 authors...
Source
View next paperConsuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans