Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction

Neutrophil extracellular traps (NETs) are chromatin filaments released by activated polymorphonuclear neutrophils (PMNs) and decorated with granule proteins with various properties. Several lines of evidence implicate NETs in thrombosis. The functional significance and the in vivo relevance of NETs during atherothrombosis in humans have not been addressed until now.Selective sampling of thrombotic material and surrounding blood from the...