Estrone – a partial estradiol antagonist in the normal breast
Abstract
Oral hormone replacement therapy (HRT) based on estradiol-17β (E2) greatly increases circulating estrone (E1) levels. E1 is an estrogen receptor agonist but may also be a partial E2 antagonist. We investigated the effects of circulating E1 on the association between circulating E2 and the increase in mammographic density (∂MD) in 46 healthy post-menopausal women treated with E2 2 mg and norethisterone acetate 1 mg daily. MD and serum E1 and E2...
Paper Details
Title
Estrone – a partial estradiol antagonist in the normal breast
Published Date
Jul 20, 2015
Journal
Volume
31
Issue
9
Pages
747 - 749
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