TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1
Abstract
TRPC3 is a non-selective cation channel, which forms a Ca2+ entry pathway involved in cardiac remodelling. Our aim was to analyse acute electrophysiological and contractile consequences of TRPC3 activation in the heart.We used a murine model of cardiac TRPC3 overexpression and a novel TRPC3 agonist, GSK1702934A, to uncover (patho)physiological functions of TRPC3. GSK1702934A induced a transient, non-selective conductance and prolonged action...
Paper Details
Title
TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1
Published Date
Jan 28, 2015
Journal
Volume
106
Issue
1
Pages
163 - 173
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