Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling
Abstract
The Insulin signaling pathway couples growth, development and lifespan to nutritional conditions. Here, we demonstrate a function for the Drosophila lipoprotein LTP in conveying information about dietary lipid composition to the brain to regulate Insulin signaling. When yeast lipids are present in the diet, free calcium levels rise in Blood Brain Barrier glial cells. This induces transport of LTP across the Blood Brain Barrier by two LDL...
Paper Details
Title
Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling
Published Date
Oct 2, 2014
Journal
Volume
3
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