Ketogenic diet protects the hippocampus from kainic acid toxicity by inhibiting the dissociation of bad from 14‐3‐3

The ketogenic diet (KD) is often effective for intractable epilepsy, but its antiepileptic mechanisms remain largely unknown. Within the cell death/survival pathway, Akt and its downstream protein Bad play an important role in kainic acid (KA)‐induced cell death. Therefore, we investigated the effects of a KD on KA‐induced changes in the Akt/Bad/14‐3‐3 signaling pathway by evaluating Akt, Bad, 14‐3‐3, and cleaved caspase‐3 expression levels as...