Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia
Abstract
Pre-eclampsia (PE) is associated with decreased nitric oxide (NO) formation. However, no previous study has examined whether genetic variations in the endothelial NO synthase (eNOS) affect this alteration. We hypothesized that PE decreases NO formation depending on eNOS polymorphisms. We examined how three eNOS polymorphisms [T-786C, rs2070744; Glu298Asp, rs1799983; 27 bp variable number of tandem repeats (VNTR) in intron 4] affect plasma...
Paper Details
Title
Effects of eNOS polymorphisms on nitric oxide formation in healthy pregnancy and in pre-eclampsia
Published Date
May 10, 2010
Journal
Volume
16
Issue
7
Pages
506 - 510
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