Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
Volume: 117, Issue: 10, Pages: 2877 - 2888
Published: Oct 1, 2007
Abstract
Obesity is associated with a state of chronic, low-grade inflammation characterized by abnormal cytokine production and macrophage infiltration into adipose tissue, which may contribute to the development of insulin resistance. During immune responses, tissue infiltration by macrophages is dependent on the expression of osteopontin, an extracellular matrix protein and proinflammatory cytokine that promotes monocyte chemotaxis and cell motility....
Paper Details
Title
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
Published Date
Oct 1, 2007
Volume
117
Issue
10
Pages
2877 - 2888
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