A G Protein-coupled Receptor Responsive to Bile Acids
Abstract
So far some nuclear receptors for bile acids have been identified. However, no cell surface receptor for bile acids has yet been reported. We found that a novel G protein-coupled receptor, TGR5, is responsive to bile acids as a cell-surface receptor. Bile acids specifically induced receptor internalization, the activation of extracellular signal-regulated kinase mitogen-activated protein kinase, the increase of guanosine 5′-O-3-thio-triphosphate...
Paper Details
Title
A G Protein-coupled Receptor Responsive to Bile Acids
Published Date
Mar 1, 2003
Volume
278
Issue
11
Pages
9435 - 9440
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