Regulation Mechanisms and Signaling Pathways of Autophagy
Abstract
Autophagy is a process of self-degradation of cellular components in which double-membrane autophagosomes sequester organelles or portions of cytosol and fuse with lysosomes or vacuoles for breakdown by resident hydrolases. Autophagy is upregulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation, ER stress, and pathogen infection. Defective autophagy plays a significant role in human...
Paper Details
Title
Regulation Mechanisms and Signaling Pathways of Autophagy
Published Date
Dec 1, 2009
Journal
Volume
43
Issue
1
Pages
67 - 93
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Notes
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