Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells
Abstract
The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular α subunits and two β subunits with tyrosine kinase activity. The IGF-1R is frequently upregulated in cancers and signals from the cell surface to promote proliferation and cell survival. Recent attention has focused on the IGF-1R as a target for cancer treatment. Here, we report that the nuclei of human tumor cells contain...
Paper Details
Title
Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells
Published Date
Aug 14, 2010
Journal
Volume
70
Issue
16
Pages
6412 - 6419
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