Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings

Published on Dec 1, 2014in BMC Complementary and Alternative Medicine2.48
· DOI :10.1186/1472-6882-14-511
Susan Arentz4
Estimated H-index: 4
(University of Western Sydney),
Jason Abbott23
Estimated H-index: 23
(UNSW: University of New South Wales)
+ 1 AuthorsAlan Bensoussan28
Estimated H-index: 28
(University of Western Sydney)
Background Polycystic ovary syndrome (PCOS) is a prevalent, complex endocrine disorder characterised by polycystic ovaries, chronic anovulation and hyperandrogenism leading to symptoms of irregular menstrual cycles, hirsutism, acne and infertility. Evidence based medical management emphasises a multidisciplinary approach for PCOS, as conventional pharmaceutical treatment addresses single symptoms, may be contra-indicated, is often associated with side effects and not effective in some cases. In addition women with PCOS have expressed a strong desire for alternative treatments. This review examines the reproductive endocrine effects in PCOS for an alternative treatment, herbal medicine. The aim of this review was to identify consistent evidence from both pre-clinical and clinical research, to add to the evidence base for herbal medicine in PCOS (and associated oligo/amenorrhoea and hyperandrogenism) and to inform herbal selection in the provision clinical care for these common conditions.
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  • References (108)
  • Citations (18)
Published on Jan 1, 2007
Ricardo Azziz65
Estimated H-index: 65
(Georgia Regents University),
Enrico Carmina45
Estimated H-index: 45
(University of Palermo)
+ 7 AuthorsBulent O. Yildiz26
Estimated H-index: 26
(Hacettepe University)
Polycystic ovary syndrome (PCOS) is a common disorder affecting (depending on the population studied and the definition of the syndrome) between 5 to 20% of reproductive age women.1 If the middle of this range is considered as a realistic prevalence, then PCOS may be the most prevalent endocrine disorder in women. In spite of the widespread presence of PCOS, its precise definition still eludes both investigators and practitioners. Most consensus definitions describe PCOS as a disorder characteri...
Published on Jul 1, 2014in Gynecological Endocrinology1.41
Ahmed Y. Shahin13
Estimated H-index: 13
(Assiut University),
Safwat A. Mohammed1
Estimated H-index: 1
(Assiut University)
AbstractBackground: Owing to their potential to act as estrogen receptor modulators and interfere with aromatase enzyme in animal studies, phytoestrogens (PE) may be useful as part of ovulation induction for polycystic ovary syndrome (PCOS).Patients and methods: Patients <35 years, presenting with infertility and PCOS, were included and randomly allocated to either group I (clomiphene citrate; CC) or group II (CC plus Cimicifugae racemosae; CR). Primary outcome was pregnancy rate. Secondary outc...
Published on Jan 1, 2014in Advances in integrative medicine
Amie Steel15
Estimated H-index: 15
(UTS: University of Technology, Sydney),
Jon Wardle14
Estimated H-index: 14
(UTS: University of Technology, Sydney)
+ 2 AuthorsJon Adams34
Estimated H-index: 34
(UTS: University of Technology, Sydney)
Abstract Objectives Despite high community use of complementary and alternative medicine (CAM) poor collaboration between conventional and CAM practitioners have been identified in many health sectors including maternity care. This is in part associated with a deficit in the formal training of CAM practitioners which overlooks collaborative practice skills and guidelines. This study evaluates the outcomes of an interprofessional education workshop which endeavours to improve the collaborative pr...
Published on Jan 1, 2014
Farzad Najafipour5
Estimated H-index: 5
Alireza Ostad Rahimi1
Estimated H-index: 1
+ 3 AuthorsAkbar Aliasgharzadeh2
Estimated H-index: 2
Nowadays, the use of alternative medicine and complementary medicine more attention is to treat a variety of diseases and the use of herbal medicines for the treatment of various disorders of the body is considered by investigators and physicians in most clinical areas. The aim of this study was to evaluate the therapeutic effects of Urtica Dioica in women with Hyperandrogenism. In a randomized controlled clinical trial that performed in Endocrinology and Metabolism clinics of Emam Reza Hospital...
Published on Jan 1, 2014in The Journal of Clinical Endocrinology and Metabolism5.61
Helena Teede48
Estimated H-index: 48
(Monash University, Clayton campus),
Melanie Gibson-Helm13
Estimated H-index: 13
(Monash University, Clayton campus)
+ 1 AuthorsJacqueline Boyle16
Estimated H-index: 16
(Monash University, Clayton campus)
Context: Polycystic ovary syndrome (PCOS) is an under-recognized, common, and complex endocrinopathy. The name PCOS is a misnomer, and there have been calls for a change to reflect the broader clinical syndrome. Objective: The aim of the study was to determine perceptions held by women and primary health care physicians around key clinical features of PCOS and attitudes toward current and alternative names for the syndrome. Design: We conducted a cross-sectional study utilizing a devised questio...
Published on Dec 1, 2013in BMC Complementary and Alternative Medicine2.48
Caroline Smith31
Estimated H-index: 31
(University of Western Sydney),
Deborah Bateson13
Estimated H-index: 13
Edith Weisberg24
Estimated H-index: 24
Background Complementary medicines (CMs) are widely used by women. Although, women in Australia are frequent users of CM, few studies have examined their utilisation by women attending a family planning service. The aim of this study was to examine (i) the extent of and type of CM, (ii) women’s views about safety and efficacy, and (iii) the factors influencing women’s decision-making.
Published on Nov 1, 2013in Phytotherapy Research3.77
Nasrin Jalilian4
Estimated H-index: 4
(Kermanshah University of Medical Sciences),
Masoud Modarresi6
Estimated H-index: 6
(Kermanshah University of Medical Sciences)
+ 2 AuthorsMohammadreza Bozorgmanesh13
Estimated H-index: 13
(Shahid Beheshti University of Medical Sciences and Health Services)
Pharmacological treatments of polycystic ovary syndrome (PCOS) have side effects. We compared the efficacy and safety of the aerial parts of wood botany (AWB) with those of Medroxyprogesterone acetate (MPA) in the management of abnormal uterine bleeding (AUB) due to PCOS. We conducted a randomized clinical trial of 66 women aged 15–45 years, with AUB. Participants were randomly assigned to either cyclical 10-mg BD MPA for three cycles or 5 g ABW TDS for three months. Clinical symptoms and paracl...
Hany H. Kamel1
Estimated H-index: 1
(Minia University)
Abstract Objective To study the role of a phyto-oestrogen, Cimicifuga racimosa extract (Klimadynon ® , Bionorica, Neumarkt i.d.OBf., Germany), in ovulation induction in women with polycystic ovarian syndrome (PCOS). Study design Prospective randomized controlled trial in Minia University Hospital, Minia, Egypt. One hundred women with PCOS were allocated into one of two groups: one group ( n = 50) received clomiphene citrate 100 mg daily for 5 days, and the other group ( n = 50) received C. racim...
Published on Jan 1, 2013in avicenna journal of phytomedicine
Valiollah Hajhashemi18
Estimated H-index: 18
Vahid Klooshani1
Estimated H-index: 1
This study was aimed to examine the antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models. Materials and Methods: Hydroalcoholic extract of the plant leaves was prepared by percolation method. Male Swiss mice (25-35 g) and male Wistar rats (180-200 g) were randomly distributed in control, standard drug, and three experimental groups (n=6 in each group). Acetic acid-induced writhing, formalin test, and carrageenan-induced paw edema were used to assess the an...
Cited By18
Published on Jul 1, 2019in Journal of Ethnopharmacology3.41
Wan-Ting Liao (PRC: China Medical University (PRC)), Cheng-Chiung Su (KMU: Kaohsiung Medical University)+ 4 AuthorsHung-Rong Yen20
Estimated H-index: 20
Abstract Ethnopharmacological relevance Polycystic ovary syndrome (PCOS) is a common condition that affects 5%–10% of women of reproductive age worldwide. Patients with PCOS have a high degree of insulin resistance and are at an increased risk of developing type 2 diabetes mellitus (T2DM). The currently available therapeutic approaches for PCOS mainly focus on symptomatic treatment. Aim of the study This study aimed to determine whether Chinese herbal medicine (CMH)-based interventions could red...
Published on Apr 1, 2019in Journal of Herbal Medicine1.55
F. Ghavi , M. Taghizadeh + 1 AuthorsSomayeh Abdolahian5
Estimated H-index: 5
Abstract Background Polycystic ovarian syndrome (PCOS) is the most common cause of ovulatory infertility with an endocrine origin. An alternative therapy for PCOS is complementary medicine (CM), with herbal medicine becoming the most popular during the past ten years. The fennel plant (Foeniculum Vulgare Mill) belongs to the flowering plant of the fennel Apiaceae family. It is a medicinal plant that is commonly recommended by practitioners of Iranian traditional medicine for ovarian or unknown i...
Published on Feb 3, 2019in Advances in Pharmacological Sciences
Mohammed Azeemuddin4
Estimated H-index: 4
(The Himalaya Drug Company),
Suryakanth D. Anturlikar8
Estimated H-index: 8
(The Himalaya Drug Company)
+ 5 AuthorsParamesh Rangesh2
Estimated H-index: 2
(The Himalaya Drug Company)
The objective of the present study was to evaluate “DXB-2030,” a polyherbal combination of Trigonella foenum-graecum, Aloe vera, Sphaeranthus indicus, Nardostachys jatamansi, and Symplocos racemosa extracts in an experimental model of testosterone propionate (TP), induced polycystic ovary syndrome (PCOS) in female rats. Thirty animals were divided into 3 groups of 10 each; group 1 served as normal control; group 2 was administered with TP and served as positive control; along with TP, group 3 wa...
Published on Dec 1, 2018in Molecular Biology Reports2.11
Balraj Singh Gill7
Estimated H-index: 7
Richa Mehra2
Estimated H-index: 2
+ 1 AuthorsS. Kumar74
Estimated H-index: 74
Sehar Toosy (Lancaster University), Ravinder Sodi5
Estimated H-index: 5
(University Hospitals of Morecambe Bay NHS Foundation Trust),
Joseph M. Pappachan13
Estimated H-index: 13
(United Lincolnshire Hospitals NHS Trust)
Background Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of reproductive age. Common features include menstrual irregularities, hyperandrogenism and polycystic ovarian morphology although the presentation can be heterogeneous. Insulin resistance is thought to be responsible for the hormonal and metabolic derangements observed. PCOS has two phenotypes, overweight/obese and lean, the latter being a much less common presentation of the syndrome.
Published on Dec 1, 2018in Scientific Reports4.01
Amie Steel15
Estimated H-index: 15
(UTS: University of Technology, Sydney),
Erica McIntyre6
Estimated H-index: 6
(UTS: University of Technology, Sydney)
+ 5 AuthorsJane Frawley11
Estimated H-index: 11
(UTS: University of Technology, Sydney)
In order to describe the prevalence and characteristics of complementary medicine (CM) practice and product use by Australians, we conducted a cross-sectional online survey with Australian adults aged 18 and over. Rates of consultation with CM practitioners, and use of CM products and practices were assessed. The sample (n = 2,019) was broadly representative of the Australian population. Prevalence of any CM use was 63.1%, with 36% consulting a CM practitioner and 52.8% using any CM product or p...
Published on Dec 1, 2018in Erfahrungsheilkunde
Die naturheilkundliche Behandlung einer Sterilitat birgt grose Chancen. Verschiedene Studien zeigen, dass die Verbesserung der Lebensstilfaktoren die spontane Schwangerschaftsrate mindestens verdoppeln kann. Die zuverlassigsten Daten liegen zur Optimierung des Lebensstils, der Ernahrung und Nahrungserganzung vor. Nach der Basisdiagnostik zu den Sterilitatsursachen konnen jedoch auch weitere naturheilkundliche Methoden erganzend genutzt werden, um den unerfullten Kinderwunsch zu behandeln.
Seema Patel21
Estimated H-index: 21
(SDSU: San Diego State University)
Abstract Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affec...
Published on Aug 1, 2018in Nutrition Research2.63
Vahid Maleki1
Estimated H-index: 1
Azimeh Izadi2
Estimated H-index: 2
+ 1 AuthorsMohammad Alizadeh10
Estimated H-index: 10
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, and recently, chromium was discussed as an adjuvant way to manage it. Herein, a systematic review was conducted which centered on the effects of chromium on ovarian physiology with a focus on body mass index, as well as hormonal and metabolic dysfunctions in women suffering from PCOS. This review was performed using the guidelines from Preferred Reporting Items for Systematic Reviews . Clini...