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Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings
Abstract
Background Polycystic ovary syndrome (PCOS) is a prevalent, complex endocrine disorder characterised by polycystic ovaries, chronic anovulation and hyperandrogenism leading to symptoms of irregular menstrual cycles, hirsutism, acne and infertility. Evidence based medical management emphasises a multidisciplinary approach for PCOS, as conventional pharmaceutical treatment addresses single symptoms, may be contra-indicated, is often associated with side effects and not effective in some cases. In addition women with PCOS have expressed a strong desire for alternative treatments. This review examines the reproductive endocrine effects in PCOS for an alternative treatment, herbal medicine. The aim of this review was to identify consistent evidence from both pre-clinical and clinical research, to add to the evidence base for herbal medicine in PCOS (and associated oligo/amenorrhoea and hyperandrogenism) and to inform herbal selection in the provision clinical care for these common conditions.
  • References (109)
  • Cited By (16)
Milewicz A1
Estimated H-index: 1
,
Gejdel E1
Estimated H-index: 1
,
Sworen H1
Estimated H-index: 1
... more
The efficacy of a Vitex agnus castus preparation (Strotan® capsules) was investigated in a randomized double blind study vs. placebo. This clinical study involved 52 women with luteal phase defects due to latent hyperprolactinaemia. The daily dose was one capsule (20 mg) Vitex agnus castus preparation and placebo, respectively
Cited 55 Source
Anthony A. Luciano1
Estimated H-index: 1
(Tufts Medical Center),
Frederick K. Chapler1
Estimated H-index: 1
(Tufts Medical Center),
Barry M. Sherman1
Estimated H-index: 1
(Tufts Medical Center)
With the use of multiple blood sampling, the prevalence of hyperprolactinemia in 150 consecutive patients with polycystic ovary syndrome (PCO) was found to be 17%. To further compare these two groups of PCO patients, the pituitary responses to gonadotropin-releasing hormone and thyrotropin-releasing hormone and the adrenal responses to dexamethasone suppression and adrenocorticotropic hormone stimulation were evaluated in 40 normoprolactinemic and 10 hyperprolactinemic PCO patients. Adrenal and ...
Ref 20Cited 79
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Ézer A. Melo1
Estimated H-index: 1
,
Eduardo B. Bertero3
Estimated H-index: 3
,
Luiz A. S. Rios1
Estimated H-index: 1
... more
Objectives: In spite of its historical use, published data about phytotherapic products is characterized by the absence of well conducted studies, leading to conflictive and indefinite results about efficiency and safety of theses drugs. In that sense, we have analyzed the results of a combination of Pygeum africanum and stinging nettle (Urtica dioica) extracts in patients with benign prostatic hyperplasia (BPH), based in a double-blind, randomized, placebo-controlled protocol. Materials and Met...
Ref 12Cited 18
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2013 in Phytotherapy Research [IF: 3.09]
Nasrin Jalilian4
Estimated H-index: 4
(Kermanshah University of Medical Sciences),
Masoud Modarresi1
Estimated H-index: 1
(Kermanshah University of Medical Sciences),
Mansour Rezaie1
Estimated H-index: 1
... more
Pharmacological treatments of polycystic ovary syndrome (PCOS) have side effects. We compared the efficacy and safety of the aerial parts of wood botany (AWB) with those of Medroxyprogesterone acetate (MPA) in the management of abnormal uterine bleeding (AUB) due to PCOS. We conducted a randomized clinical trial of 66 women aged 15–45 years, with AUB. Participants were randomly assigned to either cyclical 10-mg BD MPA for three cycles or 5 g ABW TDS for three months. Clinical symptoms and paracl...
Ref 31Cited 5
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2003 in Planta Medica [IF: 2.34]
Hubertus Jarry45
Estimated H-index: 45
,
Barbara Spengler10
Estimated H-index: 10
,
Andrea Porzel26
Estimated H-index: 26
... more
Recent cell culture experiments indicated that extracts of Vitex agnus-castus (VAC) may contain yet unidentified phytoestrogens. Estrogenic actions are mediated via estrogen receptors (ER). To investigate whether VAC compounds bind to the currently known isoforms ERa or ERss, ligand binding assays (LBA) were performed. Subtype specific ER-LBA revealed a binding of VAC to ERss only. To isolate the ERss-selective compounds, the extract was fractionated by bio-guidance. The flavonoid apigenin was i...
Cited 45
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A Dehghan1
Estimated H-index: 1
(Islamic Azad University),
A Esfandiari1
Estimated H-index: 1
(Islamic Azad University),
S Momeni Bigdeli1
Estimated H-index: 1
(Islamic Azad University)
Contents Tribulus terrestris has long been used in traditional medicine to treat impotency and improve sexual functions in man. The aim of this study was to evaluate the efficiency of T. terrestris extract in the treatment of polycystic ovary (PCO) in Wistar rat. Estradiol valerate was injected to 15 mature Wistar rats to induce PCO. Rats were randomly divided into three groups (control, low-dose and high-dose groups) of five each and received 0, 5 and 10 mg of T. terrestris extract, respectivel...
Ref 20Cited 5
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Ricardo Azziz63
Estimated H-index: 63
(Georgia Regents University),
Enrico Carmina40
Estimated H-index: 40
(University of Palermo),
Zi-Jiang Chen38
Estimated H-index: 38
(Shandong University)
... more
Polycystic ovary syndrome (PCOS) is a common disorder affecting (depending on the population studied and the definition of the syndrome) between 5 and 20% of reproductive age women.1 If the middle of this range is considered as a realistic prevalence, then PCOS may be the most prevalent endocrine disorder in women. In spite of the widespread presence of PCOS, its precise definition still eludes both investigators and practitioners. Most consensus definitions describe PCOS as a disorder character...
Ref 422Cited 852
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2003 in Maturitas
Hubertus Jarry45
Estimated H-index: 45
(University of Göttingen),
Maria Metten5
Estimated H-index: 5
(University of Göttingen),
Barbara Spengler10
Estimated H-index: 10
... more
Abstract Objectives: Extracts of Black cohosh ( Cimicifuga racemosa or CR) have been used for the treatment of climacteric complaints since decades. Efficacy, particularly concerning neurovegetative and psychic symptoms, has been proven in clinical trials. As active principle yet unknown substances with selective estrogen receptor modulator (SERM) activity are assumed. Recently, evidence arose that CR may also contain dopaminergic compounds, which may contribute to the therapeutic activity of th...
Ref 25Cited 84
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  • References (109)
  • Cited By (16)
Kunyan Zhou1
Estimated H-index: 1
(Sichuan University),
Jing Zhang6
Estimated H-index: 6
(Sichuan University),
Liangzhi Xu1
Estimated H-index: 1
(Sichuan University)
... more
Background Polycystic ovarian syndrome (PCOS) is one of the most common reproductive endocrinology abnormalities, and affects 5% to 10% of women of reproductive age. Western medicines, such as oral contraceptives, insulin sensitizers and laparoscopic ovarian drilling (LOD), have been used to treat PCOS. Recently, many studies have been published that consider Chinese herbal medicine (CHM) as an alternative treatment for women with PCOS. Objectives To assess the efficacy and safety of CHM for sub...
Ref 187Cited 17
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Milena Masullo14
Estimated H-index: 14
,
Paola Montoro22
Estimated H-index: 22
,
Angela Mari8
Estimated H-index: 8
... more
Abstract During last decades an increasing number of herbal products specifically targeting women's disorders has appeared in the worldwide marketplace. This growth highlights the need for a critical evaluation of quality, safety and efficacy of these products. Analytical techniques applied to the quality control of the main medicinal plants used for women health (relief of menopause and menstrual related symptoms) have been reviewed. Thanks to the innovation in analytical technology, identifica...
Ref 265Cited 5
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Jufeng Xia7
Estimated H-index: 7
(University of Tokyo),
Yoshinori Inagaki21
Estimated H-index: 21
(University of Tokyo),
Jian-feng Zhang1
Estimated H-index: 1
(Fudan University)
... more
Chinese medicine (CM) has been used in clinical treatment for thousands of years in China, Japan, Korea, and other countries. CM is at present attracting many attentions around the world for reproductive health care and disease prevention, including treatment of female infertility. This review focuses on the CM treatment for female infertility patients, and supplies a summary on the efficacy, safety, and mechanism of some Chinese herbal medicines, herbal medicine-derived active compounds, and ac...
Ref 78Cited 4
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Ayda Hosseinkhani3
Estimated H-index: 3
(Shiraz University of Medical Sciences),
Nasrin Asadi8
Estimated H-index: 8
(Shiraz University of Medical Sciences),
Mehdi Pasalar5
Estimated H-index: 5
(Shiraz University of Medical Sciences)
... more
Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Its cause is unknown and it remains the most enigmatic of reproductive disorders. The extant written documents of Traditional Persian Medicine (TPM) – with holistic approaches towards human health – contain remedies used for centuries. Before further experimental research on any of these treatments, it is appropriate to study current related scientific evidence on their possible pharmacological...
Ref 91Cited 3
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2017 in Primary Care
Melinda Ring2
Estimated H-index: 2
(Northwestern University)
Ref 130Cited 2
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2017 in Phytotherapy Research [IF: 3.09]
Susan Arentz3
Estimated H-index: 3
(University of Sydney),
Caroline Smith31
Estimated H-index: 31
(University of Sydney),
Jason Abbott23
Estimated H-index: 23
(University of New South Wales)
... more
Polycystic ovary syndrome (PCOS) is a common, complex reproductive endocrinopathy characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries. Lifestyle modification is a first-line intervention; however, there are barriers to success for this form of self-care, and women often seek adjunct therapies including herbal medicines. This pragmatic, randomized controlled trial, delivered in communities of Australia in overweight women with PCOS, compared the effectiveness and sa...
Ref 55Cited 6
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Susan Arentz3
Estimated H-index: 3
(University of Sydney),
Caroline Smith31
Estimated H-index: 31
(University of Sydney),
Jason Abbott23
Estimated H-index: 23
(University of New South Wales)
... more
Polycystic ovary syndrome (PCOS) is a common, reproductive endocrinopathy associated with serious short and long term health risks. Many women with PCOS use ingestible complementary medicines. This systematic review examined the effect on menstrual regulation and adverse effects from randomised controlled trials. Randomised controlled trials (RCTs) that compared herbal or nutritional supplements to placebo or active controls in women with PCOS were eligible for inclusion. Electronic databases we...
Ref 59Cited 1
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2018 in Phytotherapy Research [IF: 3.09]
Mahdie Hajimonfarednejad2
Estimated H-index: 2
(Shiraz University of Medical Sciences),
Majid Nimrouzi6
Estimated H-index: 6
(Shiraz University of Medical Sciences),
Mojtaba Heydari9
Estimated H-index: 9
(Shiraz University of Medical Sciences)
... more
Our aim is to assess the effect of cinnamon powder capsules on insulin resistance, anthropometric measurements, glucose and lipid profiles, and androgens of women with polycystic ovarian syndrome (PCOS). Out of 80 women that were diagnosed as PCOS by Rotterdam Criteria, 66 were enrolled in this randomized double-blind placebo-controlled clinical trial. All of the PCOS women were taking medroxy progesterone acetate 10 mg/day for the last 10 days of their menstrual cycles. The cases were randomly ...
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