Stromal adipocyte PPARγ protects against breast tumorigenesis
Abstract
Peroxisome proliferator-activated receptor (PPAR)γ regulates the expression of genes essential for fat storage, primarily through its activity in adipocytes. It also has a role in carcinogenesis. PPARγ normally stops the in vivo progression of 7,12-dimethylbenz[a]anthracene (DMBA)-mediated breast tumours as revealed with PPARγ haploinsufficient mice. Since many cell types associated with the mammary gland express PPARγ, each with unique signal...
Paper Details
Title
Stromal adipocyte PPARγ protects against breast tumorigenesis
Published Date
May 11, 2012
Journal
Volume
33
Issue
7
Pages
1412 - 1420
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