How Is Methane Formed and Oxidized Reversibly When Catalyzed by Ni‐Containing Methyl‐Coenzyme M Reductase?

Ni‐containing methyl‐coenzyme M reductase (MCR) is capable of catalyzing methane formation and has recently been observed to also be able to catalyze the reverse reaction, the anaerobic oxidation of methane. The forward reaction has been extensively studied theoretically before and was found to consist of two steps. The first step is rate‐limiting and the second step was therefore treated at a lower level. For an accurate treatment of the...