Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency

Volume: 10, Issue: 2, Pages: e1003962 - e1003962
Published: Feb 20, 2014
Abstract
Herpesviruses establish a lifelong latent infection posing the risk for virus reactivation and disease. In cytomegalovirus infection, expression of the major immediate early (IE) genes is a critical checkpoint, driving the lytic replication cycle upon primary infection or reactivation from latency. While it is known that type I interferon (IFN) limits lytic CMV replication, its role in latency and reactivation has not been explored. In the model...
Paper Details
Title
Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency
Published Date
Feb 20, 2014
Volume
10
Issue
2
Pages
e1003962 - e1003962
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