A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure
Abstract
Myosin light-chain kinase (MYLK) is a gene known to be significantly associated with severe asthma in African Americans. Here we further examine the molecular function of a single-nucleotide polymorphism (SNP), located in the non-muscle myosin light-chain kinase isoform (nmMLCK), in asthma susceptibility and pathobiology. We identified nmMLCK variant (reference SNP: rs9840993, NM_053025: 721C>T, c.439C>T) with a distinct mRNA secondary structure...
Paper Details
Title
A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure
Published Date
Oct 1, 2014
Volume
23
Issue
6
Pages
874 - 876
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