Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects.

Volume: 258, Issue: 4, Pages: 591 - 598
Published: Oct 1, 2013
Abstract
Multiple organ dysfunction syndrome (MODS) is a common and potentially fatal consequence of severe injury. Although mitochondrial and bioenergetic dysfunction have been incriminated in the pathogenesis of MODS for many years,1–6 involvement of mitochondria-derived mediators may be more dynamic than previously appreciated. In this regard, fragments of the mitochondrial genome released into the circulation after injury—termed mtDNA...
Paper Details
Title
Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects.
Published Date
Oct 1, 2013
Volume
258
Issue
4
Pages
591 - 598
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