Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor
Abstract
The search of small molecules as protein-protein interaction inhibitors represents a new attractive strategy to develop anti-HIV-1 agents. We previously reported a computational study that led to the discovery of new inhibitors of the interaction between enzyme HIV-1 integrase (IN) and the nuclear protein lens epithelium growth factor LEDGF/p75.(1) Herein, we describe new findings about the binding site of LEDGF/p75 on IN employing a different...
Paper Details
Title
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor
Published Date
Nov 1, 2010
Volume
18
Issue
21
Pages
7515 - 7521
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